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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nicotine improves Morris water task performance in rats given medial frontal cortex lesions.
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Nicotine improves Morris water task performance in rats given medial frontal cortex lesions.

机译：尼古丁改善了内侧额叶皮层病变大鼠的莫里斯水任务表现。

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摘要

The object of this study was to investigate whether nicotine would improve cognitive impairments produced by medial frontal cortex lesions in rats behaviorally tested on the Morris water task (MWT). Rats were assigned to either a lesion or sham group. In the lesion group, animals were given vehicle (peanut oil) treatment or treatment with nicotine for 11 consecutive days before, after, or before and after a medial frontal cortex lesion. Additionally, a sham group was included that was given vehicle both before and after the lesion. Results showed that lesioned rats receiving pre- or post-operative nicotine treatment demonstrated improved Morris task acquisition performance relative to the lesioned group given the vehicle, although a deficit was shown relative to shams. On the probe trial, rats that received a pre- and post-treatment of nicotine demonstrated performance equivalent to shams and had significantly better performance than rats that received nicotine treatment before the lesion and lesioned animals treated with the vehicle. These results demonstrate that nicotine has therapeutic effects in rats that have received cortical injury.
机译：这项研究的目的是研究尼古丁是否可以改善由莫里斯水任务（MWT）进行行为测试的大鼠的额叶内侧内侧皮损所产生的认知障碍。将大鼠分为病变或假手术组。在病变组中，在内侧额叶皮质病变之前，之后或之前和之后连续11天给动物施用媒介物（花生油）或尼古丁治疗。另外，包括假手术组，其在病变之前和之后均给予媒介物。结果显示，与给予媒介物的病变组相比，接受术前或术后尼古丁治疗的病变大鼠表现出更好的Morris任务获取性能，尽管相对于假肢而言表现出不足。在探查试验中，接受尼古丁治疗前后的大鼠表现出与假肢相当的性能，并且比在病变部位和接受媒介物治疗的病变动物接受烟碱治疗的大鼠表现出明显更好的性能。这些结果表明，尼古丁对已遭受皮质损伤的大鼠具有治疗作用。

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