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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cocaine reward and locomotor activity in C57BL/6J and 129/SvJ inbred mice and their F1 cross.
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Cocaine reward and locomotor activity in C57BL/6J and 129/SvJ inbred mice and their F1 cross.

机译：C57BL / 6J和129 / SvJ自交小鼠及其F1杂交的可卡因奖赏和运动活性。

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Large individual differences exist among mice in their behavioral responses to drugs of abuse, and many of these differences have a substantial genetic basis. The creation of new animal models using recombinant DNA technology has provided new genetic tools for assessing the role of specific candidate genes in drug response. This study presents a characterization of cocaine activation and reward in the two strains used most commonly for production of knockout mice, C57BL/6J and 129/SvJ, and their outcrossed F1 offspring. Using conditioned place preference, the study demonstrates that there are large strain differences in spontaneous locomotor activity and in the rewarding effects of cocaine. The 129/SvJ strain is hypoactive and is very sensitive to the locomotor activating effects of cocaine but does not develop cocaine-conditioned place preference under conditions that yield significant place preference in C57BL/6J mice. These phenotypes are not inherited in a simple additive manner, but rather the F1 generation resembles the C57BL/6J progenitor strain for a number of the behaviors examined.
机译：小鼠对滥用药物的行为反应存在很大的个体差异，其中许多差异具有重要的遗传基础。使用重组DNA技术创建新的动物模型，为评估特定候选基因在药物反应中的作用提供了新的遗传工具。这项研究描述了可用于生产基因敲除小鼠的两种菌株C57BL / 6J和129 / SvJ及其异交F1后代中可卡因激活和奖励的特征。使用条件性位置偏爱，该研究表明自发运动能力和可卡因的奖励作用存在很大的差异。 129 / SvJ株活性低下，对可卡因的运动激活作用非常敏感，但在C57BL / 6J小鼠中产生可卡因条件的条件下，并没有产生可卡因条件的位置偏好。这些表型不是以简单的累加方式遗传的，而是对于许多检查的行为而言，F1代都类似于C57BL / 6J祖细胞株。

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