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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats.
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Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats.

机译：戒酒症状的严重程度取决于Long-Evans大鼠的发育阶段。

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摘要

To investigate alcohol dependency and the potential role of age of initial alcohol consumption, Long-Evans (LE) rats were fed an ethanol-containing liquid diet starting at postnatal (P) ages (days): P23-27 (juvenile), P35-45 (adolescent) or P65-97 (young adult). Severity of subsequent withdrawal symptoms was dependent on age when consumption began and on duration of alcohol consumption. Frequency of withdrawal seizures was highest for rats starting consumption as juveniles, intermediate for adolescents and lowest for adults. Normalized to body weight, alcohol consumption was significantly higher for adolescent and juvenile rats than for adults. Sprague-Dawley rats that began alcohol consumption as adolescents (P35) had a level of alcohol consumption identical to that of the adolescent LE rats but showed much lower frequency of withdrawal seizures when tested after 2, 3 and 5 weeks of alcohol consumption. Based on several indicators, the capacity of the juveniles to metabolize ethanol is equal to or exceeds that of adults. Recoveries from a single dose of ethanol (2.5 g ethanol/kg body weight) were faster for juvenile LE rats than adults. The rate of decline in blood ethanol concentration was identical for juvenile and adult rats while the corrected ethanol elimination rate was higher for juveniles. The primary isozyme of alcohol dehydrogenase (ADH) in rat liver, ADH-3, had a similar Km and higher activity in liver preparations from juveniles. In conclusion, LE rats beginning alcohol consumption as juveniles or adolescents develop a severe alcohol withdrawal syndrome that may not be attributed entirely to higher levels of consumption and was not explained by any obvious deficiencies in metabolism.
机译：为了研究酒精依赖和初次饮酒年龄的潜在作用，从出生后（P）年龄（天）开始，向Long-Evans（LE）大鼠喂食含乙醇的流质饮食：P23-27（青少年），P35- 45（青少年）或P65-97（年轻人）。随后戒断症状的严重程度取决于开始饮用的年龄和饮酒的持续时间。开始作为青少年食用的大鼠的癫痫发作频率最高，青少年为中级，成年最低。按照体重标准化，青春期和少年大鼠的饮酒量明显高于成人。青春期开始饮酒的Sprague-Dawley大鼠（P35）的饮酒水平与LE青春期的大鼠相同，但是在饮酒2、3和5周后进行测试时，抽搐发作的频率要低得多。根据几个指标，青少年的乙醇代谢能力等于或超过成年人。幼年LE大鼠从单剂量乙醇（2.5 g乙醇/ kg体重）的恢复要比成年更快。幼年和成年大鼠血液中乙醇浓度的下降速率相同，而幼年中校正后的乙醇清除率则更高。大鼠肝脏中乙醇脱氢酶（ADH）的主要同工酶ADH-3具有相似的Km，在幼年肝制品中具有较高的活性。总之，从幼年或青春期开始饮酒的LE大鼠会出现严重的酒精戒断综合征，这可能不完全归因于较高的饮酒水平，也不能用任何明显的新陈代谢缺陷来解释。

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