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Antidepressant-like effect of asiaticoside in mice.

机译:积雪草苷在小鼠中的抗抑郁样作用。

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In the present study, the potential antidepressant properties of asiaticoside were investigated in male mice in three tests -- splash test in the unpredictable chronic mild stress (CMS) model, tail suspension test (TST), forced swimming test (FST) -- with clomipramine being a positive control. In the splash test, asiaticoside (10 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly augmented the frequency of grooming behavior in stressed mice. In the tail suspension test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. In the forced swimming test, asiaticoside (10, 20 mg/kg, PO) and clomipramine (50 mg/kg, PO) significantly decreased immobility time. These results suggest that asiaticoside may have antidepressant-like action.
机译:在本研究中,通过三种测试方法对雄性小鼠中积雪草苷的潜在抗抑郁特性进行了研究-不可预测的慢性轻度应激(CMS)模型中的飞溅测试,尾部悬吊测试(TST),强制游泳测试(FST)-氯米帕明为阳性对照。在飞溅试验中,积雪草苷(10 mg / kg,PO)和氯米帕明(50 mg / kg,PO)显着增加了应激小鼠的修饰行为频率。在尾部悬架测试中,积雪草苷(10、20 mg / kg,PO)和氯米帕明(50 mg / kg,PO)显着减少了固定时间。在强制游泳测试中,积雪草苷(10、20 mg / kg,PO)和氯米帕明(50 mg / kg,PO)显着减少了不动时间。这些结果表明积雪草苷可能具有抗抑郁样作用。

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