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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Isotretinoin (13-cis-retinoic acid) alters learning and memory, but not anxiety-like behavior, in the adult rat.
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Isotretinoin (13-cis-retinoic acid) alters learning and memory, but not anxiety-like behavior, in the adult rat.

机译：异维A酸（13-顺-维甲酸）改变成年大鼠的学习和记忆，但不改变焦虑样行为。

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摘要

Isotretinoin (ISO, 13-cis-retinoic acid) is commonly prescribed as Accutane for the treatment of acne. ISO is a known teratogen and the physical side effects of the drug have been well documented. However, possible psychological risks associated with the drug have yet to be determined. Retinoid receptors are abundant in the striatum and hippocampus, brain structures involved in implicit and explicit memory processes, respectively. The current study examined whether ISO influenced implicit or explicit memory processes using a two-stage radial-arm maze (RAM) task. The two stages were identical, except for the method of presenting arm choices to the rats: one at a time (Stage 1) or in pairs (Stage 2). Male rats (n=12/group) were tested on both stages of the RAM during chronic oral treatment with ISO (0, 5, 10, or 15 mg/kg/day). Performance indicated that ISO impaired explicit memory in Stage 2, but retention tests one month after ISO exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. These data indicate extensive, enduring memory effects from oral ISO treatment at doses likely to produce serum levels within the range typically used to treat acne in humans.
机译：异维A酸（ISO，13-顺-维甲酸）通常被指定为治疗痤疮的维甲酸。 ISO是一种已知的致畸剂，该药物的物理副作用已得到充分证明。但是，与该药物相关的可能的心理风险尚未确定。类维生素A受体在纹状体和海马中丰富，大脑结构分别参与内隐和外显记忆过程。当前的研究使用两步径向臂迷宫（RAM）任务检查了ISO是否影响隐式或显式存储过程。除了向大鼠展示手臂选择的方法外，这两个阶段是相同的：一次（阶段1）或成对（阶段2）。在用ISO（0、5、10或15 mg / kg /天）进行慢性口服治疗期间，在RAM的两个阶段测试了雄性大鼠（n = 12 / group）。性能表明，ISO损害了第2阶段的显性记忆，但是在ISO暴露结束后一个月的保留测试表明，该显性记忆障碍得以恢复，并且有证据表明10 mg和15 mg ISO大鼠的隐性记忆增强。这些数据表明口服ISO治疗可能产生的血清水平在通常用于治疗人类痤疮的剂量范围内，具有广泛而持久的记忆效应。

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