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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Low doses of amphetamine lead to immediate and lasting locomotor sensitization in adolescent, not adult, male rats.
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Low doses of amphetamine lead to immediate and lasting locomotor sensitization in adolescent, not adult, male rats.

机译：低剂量的苯丙胺会导致青春期（而非成年）雄性大鼠立即和持久的运动敏化。

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摘要

Although there is much evidence for age differences in behavioural responses to psychostimulants in rats, the differential, lasting impact of drug exposures has rarely been investigated using direct comparisons of adolescent and adult rats. Male rats were pre-treated with 0.5mg/kg amphetamine or saline on either postnatal days (P) 31 and P33 or P76 and P78, and locomotor activity was measured for 1h. Adolescent, and not adult, rats showed a significant increase in distance traveled from the first to second pre-treatment. There was no evidence of sensitization of locomotor activity in either adolescents or adults on Challenge 1 to the same dose of amphetamine when tested 12 days later on P45 (late adolescence) or on P90. Rats that were pre-treated as adolescents exhibited locomotor sensitization to 1.5mg/kg amphetamine as adults (P60) on Challenge 2, 27 days after pre-treatment, particularly in the group that had also received amphetamine on Challenge 1 at P45. Rats that were pre-treated as adults did not show sensitization on Challenge 2. The results suggest that the rapid adaptations to drug exposures in adolescence have greater consequences than identical treatment in adulthood, and highlight the unique vulnerability of adolescents to brief, low dose drug exposure.
机译：尽管有很多证据表明大鼠对精神兴奋药的行为反应存在年龄差异，但很少使用直接比较青春期和成年大鼠的方法来研究药物暴露的差异性，持久性影响。雄性大鼠在出生后第31天和P33或P76和P78分别用0.5mg / kg苯丙胺或生理盐水进行预处理，并测量运动能力1h。青春期大鼠（而非成年大鼠）从第一次预处理到第二次预处理的行进距离明显增加。在P45（青春期后期）或P90上测试12天后，没有证据表明在挑战1的青少年或成人中，运动能力对相同剂量的苯丙胺敏感。青春期前进行预处理的大鼠在预处理后27天，对成年2（P60）的成人表现出对1.5mg / kg苯丙胺的运动致敏性，特别是在P45时对挑战1也接受苯丙胺的组。接受成年预治疗的大鼠未对Challenge 2表现出致敏性。结果表明，与成年后的相同治疗相比，对成年后对药物暴露的快速适应具有更大的后果，并突出显示了青少年对短暂的低剂量药物的独特易感性接触。

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