• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Tolerance does not develop to the suppressant effects of (-)-norpseudoephedrine on ingestive behavior in the rat.
【24h】

Tolerance does not develop to the suppressant effects of (-)-norpseudoephedrine on ingestive behavior in the rat.

机译：对（-）-去甲伪麻黄碱对大鼠摄食行为的抑制作用没有耐受性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

-(-)-Norpseudoephedrine (NPE), the enantiomer of cathine and a structural analog of phenylpropanolamine, shows anorectic and antidipsic effects that have been referred to its structural analogies with amphetamine. When amphetamine is chronically administered to rats, its anorectic effects fade out, water intake is progressively increased, and the diuretic response to the drug remains stable. Our previous studies show that chronic administration of NPE does not produce the typical amphetamine hyperdipsic response. In the present study, designed to obtain a more detailed picture of the ingestive and diuretic effects of chronic exposure to NPE, we evaluated the effects of 11 daily administrations of three doses of NPE (17, 32, and 56 mg/kg IP) on food and water intake, as well as on diuresis, in rats maintained in conditions of free access to food and water. Results show that all three doses inhibited food intake at 2 h, whereas only the highest dose inhibited food intake at 5 h. No differences between groups were detected at 24 h. These responses remained unchanged throughout the 11 days of treatment, and substitution of NPE with a solvent injection caused no rebound feeding. NPE treatment did not modify the ingestive response to a challenge injection of amphetamine, 0.56 and 1.0 mg/kg IP, given 1 day apart. Although NPE inhibited water intake throughout the experiment, it did so significantly only during the first 2 h postinjection. Urine output in the NPE-treated groups increased significantly on the first day only. These findings make it unlikely that the anorectic effects of NPE depend on an amphetamine-like mechanism of action. In addition, the short-lasting anorectic and antidipsic effects of NPE and the lack of tolerance to them raise the possibility of a therapeutic use of this drug as an adjuvant in the therapy of eating disorders characterized by binge episodes.
机译：-（-）-去甲伪麻黄碱（NPE）是cathine的对映异构体，是苯丙醇胺的结构类似物，显示出厌食和抗消化作用，已被称为与苯丙胺的结构类似物。将苯丙胺长期给药于大鼠后，其厌食作用逐渐消失，水的摄入量逐渐增加，并且对该药物的利尿反应保持稳定。我们以前的研究表明，长期服用NPE不会产生典型的苯丙胺过度消化反应。在本研究中，旨在更详细地了解长期暴露于NPE的摄入和利尿作用，我们评估了11种每日服用三剂NPE（17、32和56 mg / kg IP）对NPE的影响。食物和水的摄入量以及利尿时，大鼠保持在自由获取食物和水的条件下。结果表明，所有三种剂量均在2 h时抑制食物摄入，而只有最高剂量才在5 h时抑制食物摄入。在24小时未检测到组之间的差异。在治疗的11天中，这些反应保持不变，并且用溶剂注射替代NPE不会引起回弹。间隔1天，NPE治疗未改变对苯丙胺挑战性注射苯丙胺，0.56和1.0 mg / kg IP的摄入反应。尽管NPE在整个实验过程中都抑制了水的摄入，但仅在注射后的前2小时内，NPE才如此明显。仅在第一天，NPE治疗组的尿量显着增加。这些发现使得NPE的厌食作用不可能依赖于苯丙胺样作用机制。另外，NPE的持久的厌食和抗消化作用以及对它们的耐受性的缺乏增加了将该药物作为佐剂用于治疗以暴发性发作为特征的饮食的可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号