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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The antinociceptive effects of branched-chain amino acids: evidence for their ability to potentiate morphine analgesia.
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The antinociceptive effects of branched-chain amino acids: evidence for their ability to potentiate morphine analgesia.

机译：支链氨基酸的镇痛作用：它们增强吗啡镇痛能力的证据。

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摘要

The effect of branched-chain amino acids (BCAA) on pain threshold was studied in rats. Nociception was induced by the hot-plate analgesia meter, a method measuring supraspinally organized pain responses. After a single intravenous injection of BCAA (320 mg/kg), the percent change in latency time to the pain response significantly increased by 19% in 60 min, and by 22% in 75 min (p < 0.005), as compared to an injection of an equal volume of a standard concentration of an amino acid solution or physiological saline. Subsequently, we studied the interaction of BCAA with opioid-type analgesia. In combination with intravenously injected morphine (3 mg/kg), BCAA significantly potentiated and prolonged the action of morphine using the hot-plate test. From 5 min after morphine injection, the latencies to a pain response were markedly higher with the combination of BCAA and morphine (+80% and +89% at 5 min after morphine injection, if BCAA was administered 45 or 60 min prior to morphine injection, respectively)when compared with the effect of morphine alone (+13% at 5 min; p < 0.005). BCAA demonstrated analgesic effects, which, in combination with morphine, potentiated and prolonged the antinociceptive action of morphine. BCAA may represent a new adjunct treatment modality for acute and chronic pain, and give us further insight into the mechanisms of pain control.
机译：在大鼠中研究了支链氨基酸（BCAA）对疼痛阈值的影响。通过热板镇痛仪（一种测量棘上组织性疼痛反应的方法）诱发伤害感受。与静脉注射BCAA相比，单次静脉注射BCAA（320 mg / kg）后，疼痛缓解潜伏时间的百分比变化在60分钟内显着增加了19％，在75分钟内显着增加了22％（p <0.005）。注射等体积标准浓度的氨基酸溶液或生理盐水。随后，我们研究了BCAA与阿片类镇痛的相互作用。与热注射试验相结合，静脉注射吗啡（3 mg / kg）可显着增强BCAA并延长吗啡的作用。从吗啡注射后5分钟起，结合使用BCAA和吗啡，疼痛反应的潜伏期显着增加（如果在吗啡注射前45或60分钟施用BCAA，则在吗啡注射后5分钟时分别增加+ 80％和+ 89％与单独使用吗啡的效果相比（5分钟时增加13％; p <0.005）。 BCAA具有止痛作用，与吗啡合用可增强并延长吗啡的镇痛作用。 BCAA可能代表了针对急性和慢性疼痛的一种新的辅助治疗方式，使我们对疼痛控制机制有了更深入的了解。

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