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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Abnormalities in parentally rated executive function in methamphetamine/polysubstance exposed children.
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Abnormalities in parentally rated executive function in methamphetamine/polysubstance exposed children.

机译：暴露于甲基苯丙胺/多物质的儿童的父母评价的执行功能异常。

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Methamphetamine/polysubstance abuse in women of childbearing age is a major concern because of the potential long-term detrimental effects on the brain function of the fetus following in utero exposure. A battery of established tests, including the Wechsler Abbreviated Scale of Intelligence, Conners' Continuous Performance Test II, Behavioral Rating Inventory of Executive Function, the CMS Family Pictures and Dot Location tests, the Spatial Span test from the WISC-IV-Integrated, and a recently developed spatial learning and memory measure (Memory Island), was used to assess the effects of prenatal drug exposure on neurobehavioral performance. Participants were 7 to 9 year old children from similar socioeconomic backgrounds who either had (N=31) or had not (N=35) been exposed to methamphetamine/polysubstance during pregnancy. Compared to unexposed children, exposed children showed pronounced elevations (i.e. more problems) in parental ratings of executive function, including behavioral regulation and metacognition. Exposed children also exhibited subtle reductions in spatial performance in the Memory Island test. In contrast, IQ, Spatial Span, Family Pictures, Dot Location, and vigilance performance were unaffected by prenatal drug exposure history. Thus, children of women who reported using methamphetamine and other recreational drugs during pregnancy showed a selective profile of abnormalities in parentally rated executive function.
机译：育龄妇女中甲基苯丙胺/多种物质的滥用是一个主要问题，因为子宫内暴露后对胎儿脑功能的潜在长期有害影响。一系列成熟的测试，包括Wechsler简化的智能量表，Conners的持续表现测试II，执行功能的行为评分清单，CMS系列图片和点位置测试，WISC-IV集成的空间跨度测试以及最近开发的空间学习和记忆测量（记忆岛）用于评估产前药物暴露对神经行为表现的影响。参与者是来自相似社会经济背景的7至9岁的孩子，他们在怀孕期间曾（N = 31）或未曾（N = 35）接触过甲基苯丙胺/多物质。与未接触的儿童相比，接触儿童的父母对执行功能（包括行为调节和元认知）的评分明显升高（即存在更多问题）。暴露的儿童在记忆岛测试中的空间表现也有轻微下降。相反，智商，空间跨度，家庭照片，点位置和警惕性不受产前药物暴露史的影响。因此，报告在怀孕期间使用甲基苯丙胺和其他休闲药物的妇女儿童表现出选择性的父母评定的执行功能异常。

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