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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Serotonin agonist-induced decreases in intermale aggression are dependent on brain region and receptor subtype.
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Serotonin agonist-induced decreases in intermale aggression are dependent on brain region and receptor subtype.

机译：血清素激动剂诱导的男性间侵略性降低取决于大脑区域和受体亚型。

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摘要

Testosterone (T) and its androgenic and estrogenic metabolites modulate the ability of serotonin (5-HT)1A and 5-HT1B agonists to inhibit intermale aggressive behavior. This study tested whether the lateral septum (LS) and medial preoptic area (MPO), which are part of the neuroanatomical substrate for aggression and contain androgen, estrogen, 5-HT1A and 5-HT1B receptors, represent sites where these modulatory effects occur. Gonadectomized CF-1 male mice were given silastic implants containing diethylstilbestrol (DES, a synthetic estrogen) or dihydrotestosterone (DHT, a nonaromatizable androgen) and implanted bilaterally with guide cannula directed at the LS or MPO. They were microinjected with either CGS12066B, a 5-HT1B agonist (400 microM LS, 200 microM MPO); 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT1A agonist (10 microM LS, 5 microM MPO); or combined CGS + 8-OH-DPAT treatment and tested for aggression 15 min later. When microinjections were given in the LS, androgen-treated males exhibited significantly reduced attack behavior in response to CGS or to CGS + 8-OH-D PAT. The attack behavior of DES-treated males was not reduced by any of the treatments. In contrast, all agonist treatments decreased aggression when injected into the MPO in both hormone conditions. The findings demonstrate regional variation in the ability of androgens and estrogens to modulate 5-HT1A- and 5-HT1B-agonist mediated reductions in aggression.
机译：睾丸激素（T）及其雄激素和雌激素代谢产物调节5-羟色胺（5-HT）1A和5-HT1B激动剂抑制男性间侵略行为的能力。这项研究测试了外侧隔（LS）和内侧视前区（MPO）是否是侵袭性神经解剖底物的一部分，并且含有雄激素，雌激素，5-HT1A和5-HT1B受体，代表这些调节作用发生的部位。将经性腺切除的CF-1雄性小鼠植入包含二乙基己烯雌酚（DES，合成雌激素）或二氢睾丸激素（DHT，不可芳香化的雄激素）的硅橡胶植入物，并用指向LS或MPO的引导套管向两侧植入。将它们与5-HT1B激动剂CGS12066B（400 microM LS，200 microM MPO）一起显微注射; 8-羟基-2-（二正丙基氨基）四氢化萘（8-OH-DPAT），5-HT1A激动剂（10 microM LS，5 microM MPO）;或联合CGS + 8-OH-DPAT处理，并在15分钟后测试其侵略性。当在LS中进行显微注射时，雄激素处理的雄性小鼠对CGS或CGS + 8-OH-D PAT的攻击行为显着降低。 DES处理的雄性的攻击行为没有通过任何一种治疗降低。相反，当在两种激素条件下注射到MPO中时，所有激动剂治疗均会降低攻击性。这些发现表明，雄激素和雌激素调节5-HT1A-和5-HT1B-激动剂介导的侵害减少的能力存在区域差异。

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