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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice.
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Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice.

机译：孕酮可减轻年轻和年长的成年C57 / BL6，野生型和孕激素受体敲除小鼠的抑郁行为。

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Progesterone may have actions independent of intracellular progestin receptors (PRs) to influence depressive behavior. To investigate this, we examined effects of progesterone (P; 10mg/kg, SC) on the depressive behavior of mice in the forced swim test (FST). In Experiment 1, subjects were 4 to 6 months old, intact or ovariectomized (OVX) female and intact or gonadectomized (GDX) male, C57/BL6 mice. Progesterone reduced depressive behavior of young diestrous and OVX mice but male mice were impervious to effects of P. In Experiment 2, subjects were intact aged (20-28 months old) C57/BL6 female and male mice. Progesterone reduced depressive behavior of aged female and male C57/BL6 mice, albeit effects were greater among males. In Experiment 3, effects of P were examined in 4 to 6 months old, gonadally-intact, female and male mice that were wildtype or PR knockouts (PRKOs). Progesterone decreased depressive behavior of young adult, wildtype and PRKO mice, which showed greater immobility than did their wildtype counterparts. In Experiment 4, subjects were 18-24 months old wildtype or PRKO mice (Exp 4). Progesterone decreased immobility among wildtype and PRKO mice (which were not different in terms of their baseline depressive behavior). Together these data demonstrate that P decreases depressive behavior of young and older adult C57/BL6, wildtype and PRKO mice, which suggest that acute anti-depressant effects of P may occur independent of actions at "classic" PRs.
机译：孕酮可能具有独立于细胞内孕激素受体（PRs）的作用，以影响抑郁行为。为了对此进行调查，我们在强制游泳测试（FST）中检查了孕酮（P; 10mg / kg，SC）对小鼠抑郁行为的影响。在实验1中，受试者为4至6个月大，雌性完整或去卵巢（OVX），雄性完整或性腺切除（GDX）C57 / BL6小鼠。孕酮可降低年轻的雌性和OVX小鼠的抑郁行为，但雄性小鼠不能受到P的影响。在实验2中，受试者为完整年龄（20-28个月大）的C57 / BL6雌性和雄性小鼠。孕酮可降低雌性和雄性C57 / BL6老年小鼠的抑郁行为，尽管对雄性小鼠的影响更大。在实验3中，在4到6个月大的性腺完好无损的雌性和雄性野生型或PR基因敲除小鼠（PRKO）中检查了P的作用。孕酮降低了成年，野生型和PRKO小鼠的抑郁行为，与野生型相比，其表现出更大的固定性。在实验4中，受试者为18-24个月大的野生型或PRKO小鼠（实验4）。孕酮降低了野生型和PRKO小鼠的固定性（就基线抑郁行为而言没有差异）。这些数据一起表明，P降低了成年和老年成年C57 / BL6，野生型和PRKO小鼠的抑郁行为，这表明P的急性抗抑郁作用可能独立于“经典” PR的作用而发生。

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