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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Role of potassium channels in the antidepressant-like effect of folic acid in the forced swimming test in mice
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Role of potassium channels in the antidepressant-like effect of folic acid in the forced swimming test in mice

机译：钾通道在小鼠强迫游泳试验中叶酸抗抑郁样作用中的作用

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Potassium (K +) channels have been implicated in depressive disorders and in the mechanism of action of antidepressants. Considering that several studies have indicated that folic acid plays an important role in the pathophysiology of depression, the present study investigated the involvement of potassium channels in the antidepressant-like effect of this vitamin. For this aim, the effect of the combined administration of different types of K + channel blockers and folic acid in the forced swimming test (FST) was investigated. Treatment of mice by intracerebroventricular (i.c.v.) route with subactive doses of glibenclamide (an ATP-sensitive K + channels blocker, 0.5 pg/site), charybdotoxin (a large- and intermediate-conductance calcium-activated K + channel blocker, 25 pg/site) or apamin (a small-conductance calcium-activated K + channel blocker, 10 pg/site), augmented the effect of folic acid (10 mg/kg, p.o., subeffective dose) in the FST. Additionally, the administration of folic acid and the K + channel blockers, alone or in combination, did not affect locomotion in the open-field test. Moreover, the reduction in the immobility time in the FST elicited by folic acid administered at a higher dose (50 mg/kg, p.o.) was prevented by the pretreatment of mice with the K + channel opener cromakalim (10 μg/site, i.c.v.), without affecting locomotor activity. The results of this study indicate that the antidepressant-like effect of folic acid in the FST may be at least partly due to its modulatory effects on neuronal excitability, via inhibition of K + channels.
机译：钾（K +）通道与抑郁症和抗抑郁药的作用机制有关。考虑到多项研究表明叶酸在抑郁症的病理生理中起着重要作用，因此本研究调查了钾通道参与该维生素的抗抑郁样作用。为此，研究了在强制游泳试验（FST）中联合使用不同类型的K +通道阻滞剂和叶酸的效果。通过脑室内（icv）途径用亚活性剂量的glibenclamide（ATP敏感的K +通道阻滞剂，0.5 pg /位），charybdoxin（大和中电导钙激活的K +通道阻滞剂，25 pg /位）治疗小鼠位点）或apaapamin（小电导钙激活的K +通道阻滞剂，10 pg /位点）增强了FST中叶酸（10 mg / kg，口服，亚有效剂量）的作用。另外，叶酸和K +通道阻滞剂的单独或组合给药在开放视野试验中不影响运动。此外，通过用K +通道开放剂克罗马卡林（10μg/位，icv）预处理小鼠，可以防止以较高剂量（50 mg / kg，po）施用叶酸引起的FST固定时间减少。 ，而不影响运动活动。这项研究的结果表明，叶酸在FST中的抗抑郁样作用可能至少部分是由于其通过抑制K +通道对神经元兴奋性的调节作用。

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