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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Assessment of the aversive effects of peripheral mu opioid receptor agonism in Fischer 344 and Lewis rats
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Assessment of the aversive effects of peripheral mu opioid receptor agonism in Fischer 344 and Lewis rats

机译：评估Fischer 344和Lewis大鼠外周阿片类阿片受体激动剂的厌恶作用

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摘要

The Fischer 344 (F344) and Lewis (LEW) inbred rat strains differ on a host of biochemical, neuroanatomical, immunological and behavioral endpoints. One behavioral difference of interest is their differential reactivity to the aversive effects of morphine as indexed by the conditioned taste aversion preparation (aversions acquired by F344 rats are significantly greater than those acquired by the LEW strain). This differential effect appears to be specific to opioids that work primarily on the mu opioid receptor. Given that morphine works systemically, it is unknown whether these differential effects in F344 and LEW animals are centrally or peripherally mediated. To address this issue, the present study investigated the ability of the peripherally acting mu preferring opioid agonist loperamide to induce differential taste aversions in F344 and LEW animals. Both F344 and LEW animals acquired dose-dependent taste aversions to the loperamide-associated solution with no difference between them. Additionally, control animals initially injected with vehicle during aversion training with loperamide and subsequently conditioned with morphine displayed the typical aversive profile to morphine (F344 > LEW). Although the basis for the present data is unknown, their relation to morphine-induced taste aversions and the role of the interaction of stimulus effects of drugs that produce differential abuse liability were discussed.
机译：Fischer 344（F344）和Lewis（LEW）自交大鼠品系在许多生化，神经解剖学，免疫学和行为学终点上有所不同。一项令人感兴趣的行为差异是它们对吗啡的厌恶反应的差异反应性，这是由条件化味觉厌恶制剂所确定的（F344大鼠获得的厌恶明显大于LEW菌株获得的厌恶）。这种差异作用似乎对主要作用于μ阿片受体的阿片类药物具有特异性。鉴于吗啡具有全身性作用，因此尚不清楚这些对F344和LEW动物的差异作用是由中央还是周边介导的。为了解决这个问题，本研究调查了喜欢阿片类激动剂洛哌丁胺的外围作用小鼠在F344和LEW动物中诱导不同的味觉厌恶的能力。 F344和LEW动物均获得了与洛哌丁胺相关溶液的剂量依赖性味觉厌恶，两者之间没有差异。此外，对照动物最初在用洛哌丁胺进行厌恶训练期间注射了媒介物，随后用吗啡进行了适应，表现出典型的对吗啡的厌恶特征（F344> LEW）。尽管目前数据的基础尚不清楚，但已讨论了它们与吗啡引起的口感厌恶的关系以及产生差异性滥用责任的药物的刺激作用相互作用的作用。

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