首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Sex differences in escape-avoidance response in mice after acute administration of raclopride, clozapine, and SCH 23390.
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Sex differences in escape-avoidance response in mice after acute administration of raclopride, clozapine, and SCH 23390.

机译:急性给予雷氯必利,氯氮平和SCH 23390后,小鼠逃避逃避反应的性别差异。

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Sex differences in the effects of haloperidol in the escape-avoidance response in mice have previously been found in various studies carried out in our laboratory. Males were more affected than females by the disruptive effects of this neuroleptic. The work described herein extended the study of these sex differences to raclopride, clozapine, and SCH 23390, using several doses of each drug in acute administration. The results showed dose-dependent sex differences in the deteriorating effects of these dopamine antagonists in the escape-avoidance response. Male mice were more affected by the inhibitory effects of these drugs, showing fewer escape responses and more nonresponses than females. Sex differences were found with all three of the dopamine antagonists studied, indicating, therefore, that these differences do not depend on a unique type of dopaminergic receptor. The results obtained in motor activity, measured by the number of crossings during the adaptation period and the intertrial intervals, suggest that the motor effects are not the origin of these differences. It is concluded that, besides haloperidol, other dopamine antagonists also show sex differences in their behavioral effects in escape-avoidance response in mice, with males being more affected than females by the inhibitory action of these drugs.
机译:氟哌啶醇在小鼠逃避逃避反应中的作用存在性别差异,此前在我们实验室进行的各种研究中均已发现。这种抗精神病药的破坏作用使男性比女性受到的影响更大。本文所述的工作,使用几种剂量的每种药物在急性给药中,将这些性别差异的研究扩展到了雷氯必利,氯氮平和SCH 23390。结果表明,这些多巴胺拮抗剂在逃避逃避反应中的恶化作用中,存在剂量依赖性的性别差异。雄性小鼠受这些药物抑制作用的影响更大,与雌性小鼠相比,逃逸反应更少,无反应更多。在研究的所有三种多巴胺拮抗剂中均发现性别差异,因此表明这些差异并不取决于独特的多巴胺能受体类型。运动能力获得的结果(通过适应期间的交叉次数和试验间隔时间来衡量)表明,运动效应并非这些差异的根源。结论是,除氟哌啶醇外,其他多巴胺拮抗剂在小鼠逃避逃避反应中的行为效应中也存在性别差异,这些药物的抑制作用使雄性比雌性受到的影响更大。

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