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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats.
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The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats.

机译：选择性5-羟色胺再摄取抑制剂氟西汀可降低雄性大鼠的性动机。

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A male rat put in an open-field arena in which it is free to spend time in the vicinity of--but not in contact with--an estrous female, or in the vicinity of a male, usually spends more time with the female than with the male or elsewhere. Tentatively, the percentage of time spent in the vicinity of the female in this paradigm may be regarded as a measure of sexual motivation. In humans, treatment with selective serotonin reuptake inhibitors (SSRIs) may cause reduced libido. To investigate to what extent serotonin reuptake inhibition influences sexual motivation also in rats, we have tested the effect of subchronic treatment with fluoxetine on the behavior in the sexual motivation test described above; in addition, the effect of fluoxetine on male copulatory behavior was studied. Fluoxetine significantly reduced sexual motivation at subchronic but not at acute administration; moreover, fluoxetine-treated rats displayed an increased ejaculation latency. It is concluded that humans and rats respond similarly to the SSRI fluoxetine with respect to various aspects of sexual behavior.
机译：一只雄性老鼠进入露天场所，可以自由地在发情的雌性动物附近（但不与之接触）或雄性动物附近度过时光而不是男性或其他地方。暂时地，在这种范例中，在女性附近度过的时间百分比可被视为性动机的量度。在人类中，使用选择性5-羟色胺再摄取抑制剂（SSRI）进行治疗可能会导致性欲降低。为了研究5-羟色胺再摄取抑制在多大程度上也影响大鼠的性动机，我们在上述性动机测试中测试了氟西汀亚慢性治疗对行为的影响。此外，还研究了氟西汀对男性交配行为的影响。氟西汀可显着降低亚慢性时的性动机，但不能降低急性期的​​性动机。此外，氟西汀治疗的大鼠表现出射精潜伏期延长。结论是，在性行为的各个方面，人和大鼠对SSRI氟西汀的反应相似。

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