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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: Neurobiological and pharmacological validity

机译：使用选择性繁殖的大鼠品系针对酒精滥用的药物开发的动物模型：神经生物学和药理学有效性

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The purpose of this review paper is to present evidence that rat animal models of alcoholism provide an ideal platform for developing and screening medications that target alcohol abuse and dependence. The focus is on the 5 oldest international rat lines that have been selectively bred for a high alcohol-consumption phenotype. The behavioral and neurochemical phenotypes of these rat lines are reviewed and placed in the context of the clinical literature. The paper presents behavioral models for assessing the efficacy of pharmaceuticals for the treatment of alcohol abuse and dependence in rodents, with particular emphasis on rats. Drugs that have been tested for their effectiveness in reducing alcohol/ethanol consumption and/or self-administration by these rat lines and their putative site of action are summarized. The paper also presents some current and future directions for developing pharmacological treatments targeting alcohol abuse and dependence.
机译：本文的目的是提供证据，证明酒精中毒的大鼠动物模型为开发和筛选针对酒精滥用和依赖性的药物提供了理想的平台。重点是针对5个最古老的国际大鼠品系，这些品系已针对高酒精消耗表型进行了选择性繁殖。这些大鼠系的行为和神经化学表型进行了审查，并将其放在临床文献中。本文提出了行为模型，用于评估药物对啮齿类动物的酒精滥用和依赖性的治疗效果，特别是对大鼠的评估。总结了已通过这些大鼠品系测试过的药物在减少酒精/乙醇消耗和/或自我给药方面的功效及其假定的作用部位。本文还为开发针对酒精滥用和依赖性的药物治疗方法提供了一些当前和未来的方向。

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