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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Gallic acid decreases vacuous chewing movements induced by reserpine in rats.
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Gallic acid decreases vacuous chewing movements induced by reserpine in rats.

机译：没食子酸减少了利血平诱导的大鼠空腹咀嚼运动。

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摘要

Involuntary oral movements are present in several diseases and pharmacological conditions; however, their etiology and efficient treatments remain unclear. Gallic acid is a natural polyphenolic acid found in gall nuts, sumac, oak bark, tea leaves, grapes and wine, with potent antioxidant and antiapoptotic activity. Thus, the present study investigated the effects of gallic acid on vacuous chewing movements (VCMs) in an animal model induced by reserpine. Rats received either vehicle or reserpine (1mg/kg/day, s.c.) during three days, followed by treatment with water or different doses of gallic acid (4.5, 13.5 or 40.5mg/kg/day, p.o.) for three more days. As result, reserpine increased the number of VCMs in rats, and this effect was maintained for at least three days after its withdrawal. Gallic acid at two different doses (13.5 and 40.5mg/kg/day) has reduced VCMs in rats previously treated with reserpine. Furthermore, we investigated oxidative stress parameters (DCFH-DA oxidation, TBARS and thiol levels) and Na(+),K(+)-ATPase activity in striatum and cerebral cortex, however, no changes were observed. These findings show that gallic acid may have promissory use in the treatment of involuntary oral movements.
机译：非自愿的口腔运动存在于多种疾病和药理学状况中。然而，他们的病因和有效的治疗方法仍不清楚。没食子酸是一种天然的多酚酸，存在于坚果，漆树，橡树皮，茶叶，葡萄和葡萄酒中，具有有效的抗氧化剂和抗凋亡活性。因此，本研究调查了没食子酸对利血平诱导的动物模型中空泡咀嚼运动（VCM）的影响。大鼠在三天内接受媒介物或利血平（1mg / kg /天，皮下注射），然后再用水或不同剂量的没食子酸（4.5、13.5或40.5mg / kg /天，口服）治疗三天。结果，利血平增加了大鼠中VCM的数量，并且这种作用在停药后至少维持了三天。两种不同剂量的没食子酸（分别为13.5和40.5mg / kg /天）在先前用利血平治疗的大鼠中降低了VCM。此外，我们调查了纹状体和大脑皮层的氧化应激参数（DCFH-DA氧化，TBARS和硫醇水平）和Na（+），K（+）-ATPase活性，但是未观察到变化。这些发现表明，没食子酸可能在非自愿性口腔运动的治疗中得到了积极应用。

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