Assessment of bleeding propensity in non-human primates by combination of selective tissue factor/VIIa inhibition and aspirin compared to warfarin and aspirin treatment.

Salyers AK; Szalony JA; Suleymanov OD; Parlow JJ; Wood RS; South MS; Nicholson NS

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Assessment of bleeding propensity in non-human primates by combination of selective tissue factor/VIIa inhibition and aspirin compared to warfarin and aspirin treatment.

机译：与华法林和阿司匹林治疗相比，通过选择性组织因子/ VIIa抑制和阿司匹林的组合评估非人灵长类动物的出血倾向。

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This study in non-human primates was designed to evaluate the bleeding propensity of a selective, small molecule inhibitor of tissue factor (TF)/VIIa in combination with acetylsalicylic acid (ASA) in comparison to the combination of ASA and warfarin. Bleeding time was increased by ASA but was not prolonged further by the addition of the TF/VIIa inhibitor, PHA-927, at doses that elevated the prothrombin time to 8-fold. In contrast, bleeding time was prolonged by warfarin alone and further exacerbated by the presence of ASA. Acute blood loss at the bleeding site, while not significantly increased by either warfarin or PHA-927, was increased substantially in several individuals treated with a combination of warfarin and ASA but not by the combination of TF/VIIa inhibitor and ASA. These data predict that TF/VIIa inhibition, in the presence of chronic aspirin therapy in patients with cardiovascular risk factors, will be a safe therapy for thrombotic disorders.

机译：这项针对非人类灵长类动物的研究旨在评估与ASA和华法林联合使用的组织因子（TF）/ VIIa选择性小分子抑制剂与乙酰水杨酸（ASA）联合使用时的出血倾向。 ASA可增加出血时间，但添加凝血酶原时间至8倍的TF / VIIa抑制剂PHA-927并不会进一步延长出血时间。相反，单独使用华法令可延长出血时间，而使用ASA则可进一步加剧出血时间。华法林或PHA-927并没有明显增加出血部位的急性失血，但在华法林和ASA联合治疗的几名患者中，出血的急性失血明显增加，但TF / VIIa抑制剂和ASA的联合治疗并未使出血量急剧增加。这些数据预测，在患有心血管危险因素的患者中进行慢性阿司匹林治疗时，TF / VIIa抑制将是治疗血栓形成性疾病的安全方法。

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《Pharmacology: International Journal of Experimental and Clinical Pharmacology》 |2004年第2期|共7页
作者
Salyers AK; Szalony JA; Suleymanov OD; Parlow JJ; Wood RS; South MS; Nicholson NS;
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正文语种 eng
中图分类药学;
关键词
Aminobenzoic Acids; Anticoagulants; Aspirin; Factor VIIa; Platelet Aggregation Inhibitors; 氨基苯甲酸类; 抗凝药; 阿司匹林; 因子ⅦA; 血小板聚集抑制剂; 吡嗪类; 凝血致活酶;

机译：Aminobenzoic Acids;Anticoagulants;Aspirin;Factor VIIa;Platelet Aggregation Inhibitors;氨基苯甲酸类;抗凝药;阿司匹林;因子ⅦA;血小板聚集抑制剂;吡嗪类;凝血致活酶;

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1. Assessment of bleeding propensity in non-human primates by combination of selective tissue factor/VIIa inhibition and aspirin compared to warfarin and aspirin treatment. [J] . Salyers AK, Szalony JA, Suleymanov OD, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 2004,第2期

机译：与华法林和阿司匹林治疗相比，通过选择性组织因子/ VIIa抑制和阿司匹林的组合评估非人灵长类动物的出血倾向。
2. Bleeding risk in randomized controlled trials comparing warfarin and aspirin: A systematic review and meta-analysis [J] . WarkentinA.E., DonadiniM.P., SpencerF.A., Journal of thrombosis and haemostasis: JTH . 2012,第4期

机译：比较华法林和阿司匹林的随机对照试验中的出血风险：系统评价和荟萃分析
3. Bleeding risks with combination of oral anticoagulation plus antiplatelet therapy: Is clopidogrel any safer than aspirin when combined with warfarin? [J] . Kok HoonTay, Deirdre A. Lane, Gregory Y. H. Lip Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2008,第6期

机译：口服抗凝结合抗血小板治疗有出血风险：与华法林合用时，氯吡格雷比阿司匹林安全吗？
4. Inhibition of platelet aggregation by aspirin alone and by aspirin in combination with clopidogrel: synergy, incompatibility and additivity [C] . Helgason, C.M., Mordeson, Fuzzy Information Processing Society, 2000. NAFIPS. 19th International Conference of the North American . 2000

机译：单独使用阿司匹林或与阿司匹林联合氯吡格雷抑制血小板聚集：协同作用，不相容性和可加性
5. Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo‐oxygenase‐2 inhibitors traditional non‐aspirin non‐steroidal anti‐inflammatory drugs aspirin and combinations [O] . A Lanas, L A García‐Rodríguez, M T Arroyo, 2006

机译：与选择性环氧合酶2抑制剂传统非阿司匹林非甾体类抗炎药阿司匹林及其组合有关的上消化道溃疡出血风险
6. Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo‐oxygenase‐2 inhibitors, traditional non‐aspirin non‐steroidal anti‐inflammatory drugs, aspirin and combinations [O] . Lanas, A, García‐Rodríguez, L A, Arroyo, M T, 2006

机译：选择性环氧合酶2抑制剂，传统非阿司匹林非甾体类抗炎药，阿司匹林及其组合导致的上消化道溃疡出血风险

Assessment of bleeding propensity in non-human primates by combination of selective tissue factor/VIIa inhibition and aspirin compared to warfarin and aspirin treatment.

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