• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of tetrabenazine on methamphetamine-induced hyperactivity in mice are dependent on order and time-course of administration.
【24h】

Effects of tetrabenazine on methamphetamine-induced hyperactivity in mice are dependent on order and time-course of administration.

机译：丁苯那嗪对小鼠甲基苯丙胺诱发的过度活跃的影响取决于给药的顺序和时间。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ambulation-increasing effect of methamphetamine (MAP: 2 mg/kg s.c.) in mice persisted for about 3 h. Tetrabenazine (TBZ: 4 mg/kg s.c.), a depleter of monoamines from the cytoplasmic pool did not increase ambulation on its own. Pretreatment with TBZ at 1.5 h before administration of MAP inhibited the stimulant effect of MAP. In contrast, combined administration of two drugs resulted in a transient but considerable enhancement of MAPs stimulant effect. Post-MAP treatment with TBZ at 0.5-2 h hardly modified MAPs behavioral effects. In contrast, 3-6 h post-MAP treatment with TBZ induced a transient increase in activity, although the stimulant effect of MAP had already disappeared. The maximum increase in ambulatory stimulation was produced by 4-h post-MAP treatment with TBZ. The inhibitory effect of TBZ pretreatment on MAP-induced hyperactivity, as well as the transient hyperactivity elicited by TBZ when administered along with MAP, or 4 h after MAP, was dose-dependent. Preliminary studies revealed that transient hyperactivity was never produced by combination of GBR-12909 (a selective dopamine reuptake inhibitor) with TBZ or MAP with oxypertine (a selective norepinephrine releaser/depleter), but produced by combination of nialamide (a monoamine oxidase inhibitor) with TBZ. Inhibition of MAPs effects by TBZ pretreatment suggests that enhancement of dopamine release from cytoplasmic pool, and inhibition of dopamine reuptake by MAP, are involved in MAPs acute behavioral effects. Further, the fact that neither TBZ administration following GBR-12909 pretreatment, nor oxypertine treatment following MAP pretreatment, elicited transient hyperactivity suggests that dopamine is involved in hyperactivity elicited by post-MAP treatment with TBZ. It is also suggested that inhibition of monoamine oxidase (MAO) by MAP and dopamine displacement by TBZ may be responsible for the transient stimulation produced by 3-6 h post-MAP treatment with TBZ. It is hypothesized that the MAO inhibitory action of MAP persists after cessation of its acute stimulant effect, possibly up to 6 h after administration.
机译：甲基苯丙胺（MAP：2 mg / kg s.c.）在小鼠中的运动增强作用持续约3小时。 Tetrabenazine（TBZ：4 mg / kg s.c.），一种从细胞质库中消耗掉的单胺，并不能增加其活动能力。在给予MAP前1.5小时用TBZ预处理抑制了MAP的刺激作用。相比之下，两种药物的联合给药导致MAPs兴奋作用的短暂但显着增强。用TBZ在0.5-2 h进行MAP后治疗几乎不能改变MAPs的行为效应。相反，虽然MAP的刺激作用已经消失，但TBZ MAP处理后3-6小时诱导了活性的瞬时增加。通过TBZ进行MAP后4小时治疗，可产生最大的动态刺激。 TBZ预处理对MAP诱导的机能亢进的抑制作用以及TBZ与MAP一起给药时或MAP后4小时引起的短暂性机能亢进是剂量依赖性的。初步研究表明，GBR-12909（一种选择性的多巴胺再摄取抑制剂）与TBZ或MAP与氧合高汀（一种选择性的去甲肾上腺素释放/耗竭剂）联合使用不会产生短暂的机能亢进，而由烟酰胺（一种单胺氧化酶抑制剂）与TBZ。 TBZ预处理对MAPs的抑制作用表明，多巴胺从细胞质库中释放的增强和MAP对多巴胺再摄取的抑制均与MAPs的急性行为影响有关。此外，GBR-12909预处理后的TBZ给药和MAP预处理后的氧高汀治疗均不会引起短暂的过度活跃，这一事实表明多巴胺与TBZ的MAP后处理所引起的过度活跃有关。还表明，MAP抑制单胺氧化酶（MAO）和TBZ取代多巴胺可能是TBZ MAP处理3-6小时后产生的短暂刺激的原因。据推测，MAP的MAO抑制作用在其急性刺激作用停止后持续存在，可能在给药后长达6小时。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号