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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Tolerance to the anticonflict effects of diazepam: importance of methodological considerations.
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Tolerance to the anticonflict effects of diazepam: importance of methodological considerations.

机译：耐受地西epa的抗冲突作用：方法学考虑的重要性。

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摘要

The present study examines the effects of chronic diazepam treatment on conflict behavior in rats using the Geller-Seifter paradigm. A dose-response function for the effects of diazepam (DZ) on punished and unpunished responding was determined (0.0, 0.63, 1.25, 2.5, and 5.0 mg/kg DZ intraperitoneally) using five independent groups. The test doses of DZ produced an inverted U-shaped function where punished responding increased as a function of dose up to 2.5 mg/kg and then decreased at 5.0 mg/kg. All groups were then treated with 2 x 5 mg/kg DZ per day for 5 days. When the dose-response function was redetermined at 36 h post-chronic treatment, it was found that the function had shifted to the right, indicating tolerance. Because of the inverted U-shaped nature of the original function, tolerance was manifested as a decrease in responding on the ascending portion of the function and as an increase in responding on the dose (5 mg/kg) representing the descending side of the inverted U.
机译：本研究使用Geller-Seifter范式研究了慢性地西epa治疗对大鼠冲突行为的影响。使用五个独立的组，确定了地西epa（DZ）对受罚和未受惩罚的响应的剂量响应功能（腹膜内分别为0.0、0.63、1.25、2.5和5.0 mg / kg DZ）。 DZ的测试剂量产生倒U形功能，其中惩罚响应随着剂量的增加而增加，直至2.5 mg / kg，然后以5.0 mg / kg降低。然后将所有组每天用2 x 5 mg / kg DZ治疗5天。当在慢性治疗后36小时重新确定剂量反应功能时，发现该功能已向右移动，表明耐受。由于原始功能的倒U形性质，耐受性表现为对功能的上升部分的响应减少，以及对代表倒立的下降侧的剂量（5 mg / kg）的响应增加。

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