Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists.

McLaughlin PJ; Winston KM; Swezey LA; Vemuri VK; Makriyannis A; Salamone JD

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Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists.

机译：对食品增强操作杆按压的详细分析可区分大麻素CB1反向激动剂和多巴胺D1和D2拮抗剂的作用。

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Overt similarities exist between the effects of systemic cannabinoid CB1 inverse agonists and dopamine (DA) antagonists on appetitive behavior. The present set of studies was undertaken to apply a fine-grained analysis of food-reinforced operant lever pressing in rats in order to compare the pattern of effects produced by administration of the CB1 inverse agonist AM 251 and those induced by the DA D1 antagonist SKF 83566, and the D2 antagonist raclopride. Three groups of rats were trained on a fixed-ratio 5 (FR5) schedule and administered these compounds over a range of doses expected to suppress responding. All three drugs produced a dose-related suppression of total lever pressing. In addition to main effects of dose, regression analyses were performed to determine which of several response timing- and rate-related variables correlated most strongly with overall responding in each group. It was found that total session time spent pausing from responding was significantly better at predicting responding in the AM 251 group, while both DA antagonists produced significantly stronger regression coefficients (versus AM 251) from fast responding measures. These results suggest that, while several similarities exist, CB1, D1, and D2 antagonists are not identical in their pattern of suppression of food-maintained lever pressing.

机译：全身性大麻素CB1反向激动剂和多巴胺（DA）拮抗剂对食欲行为的影响之间存在明显相似性。进行本组研究以对大鼠的食物强化操作杆按压进行细粒度分析，以比较施用CB1反向激动剂AM 251和DA D1拮抗剂SKF诱导产生的作用方式83566和D2拮抗剂雷洛必利。按固定比例5（FR5）的时间表训练三组大鼠，并以预期抑制反应的一定剂量范围内使用这些化合物。所有这三种药物都产生了与剂量相关的总杠杆压制抑制作用。除了剂量的主要影响外，还进行了回归分析，以确定与反应时间和速率相关的几个变量中哪一个与每个组的总体反应最相关。发现在AM 251组中，因响应而暂停的总会话时间明显好于预测响应，而两种DA拮抗剂均通过快速响应措施产生了明显更强的回归系数（相对于AM 251）。这些结果表明，尽管存在一些相似之处，但CB1，D1和D2拮抗剂在抑制食物保持的杠杆按压方面却不相同。

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《Pharmacology, Biochemistry and Behavior》 |2010年第1期|共7页
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McLaughlin PJ; Winston KM; Swezey LA; Vemuri VK; Makriyannis A; Salamone JD;
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1. Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists. [J] . McLaughlin PJ, Winston KM, Swezey LA, Pharmacology, Biochemistry and Behavior . 2010,第1期

机译：对食品增强操作杆按压的详细分析可区分大麻素CB1反向激动剂和多巴胺D1和D2拮抗剂的作用。
2. Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions. [J] . Salamone JD, McLaughlin PJ, Sink K, Physiology & behavior . 2007,第4期

机译：大麻素CB1受体反向激动剂和中性拮抗剂：对食物摄入，食物强化行为和食物厌恶的影响。
3. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists. [J] . Muccioli GG, Wouters J, Charlier C, Journal of Medicinal Chemistry . 2006,第3期

机译：1,3,5-三苯基咪唑烷-2,4-二酮和1,3,5-三苯基-2-硫氧代咪唑啉丁-4-酮的合成和活性：新的CB1大麻素受体反向激动剂/拮抗剂的表征。
4. Study of in Vitro Metabolism of LY-320135, a Novel Inverse Agonist for Cannabinoid Receptor (CB1) by HPLC-LTQ Mass Spectrometry [C] . Qiang Zhang, Peng Ma, Guangdi Wang ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：HPLC-LTQ质谱法测定大麻素受体（CB1）的新型逆激动剂的体外代谢研究
5. The role of NT1 receptor agonism in discriminative stimulus properties of a D1 or D2 dopamine receptor agonist. [D] . Rusch, Kristoffer R. 2013

机译：NT1受体激动剂在D1或D2多巴胺受体激动剂的判别刺激特性中的作用。
6. Detailed Analysis of Food-Reinforced Operant Lever Pressing Distinguishes Effects of a Cannabinoid CB1 Inverse Agonist and Dopamine D1 and D2 Antagonists [O] . P.J. McLaughlin, K.M. Winston, L.A. Swezey, -1

机译：食品增强操作杆压迫的详细分析区分大麻素CB1逆激动剂和多巴胺D1和D2拮抗剂的效果
7. Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists [O] . P.J. McLaughlin, K.M. Winston, L.A. Swezey, 2010

机译：食品增强操作杆压迫的详细分析区分大麻素CB1逆激动剂和多巴胺D1和D2拮抗剂的效果

Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists.

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