• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats.
【24h】

SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats.

机译：SB-334867-A是一种选择性的orexin-1受体拮抗剂，可增强大鼠的味觉厌恶学习并阻止其口味偏好学习。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lateral hypothalamus (LH) has been proposed as a possible center for the anatomical convergence of gustatory and postingestive information relevant to taste aversion learning (TAL) and conditioned flavor preference (CFP). Orexin, a neuropeptide that mainly originates in neurons in lateral hypothalamic areas, was recently related to learning and memory processes. The present study was designed to analyze a possible relationship between the orexinergic system and taste learning. We studied the effect of intracerebroventricular administration of three doses (3, 6, and 12 mug/1 mul) of the selective orexin-1 receptor antagonist SB-334867-A on the acquisition of TAL induced by a single administration of LiCl. Infusion of SB-334867-A did not block this learning and appeared to enhance TAL in a two-bottle test. However, SB-334867-A (6 mug/1 mul) blocked taste preference learning when a flavor associated with saccharin (CS+) was offered on alternate days against a different flavor without saccharin (CS-), during three acquisition sessions. These results offer evidence of a relationship between the orexinergic system and taste learning; they tentatively suggest the possibility that endogenous orexin and gustatory and postingestive (visceral and oral) signals converge in brain areas relevant to the acquisition of taste learning.
机译：下丘脑外侧（LH）已被提议作为与味觉厌恶学习（TAL）和条件性风味偏好（CFP）有关的味觉和味觉信息的解剖学融合的可能中心。 Orexin是一种神经肽，主要起源于下丘脑外侧区域的神经元，最近与学习和记忆过程有关。本研究旨在分析食欲系统与味觉学习之间的可能关系。我们研究了脑室内给药三种剂量（3、6和12杯/ 1 mul）的选择性orexin-1受体拮抗剂SB-334867-A对单次LiCl诱导的TAL采集的影响。输注SB-334867-A不会阻止这种学习，并且在两瓶试验中似乎可以增强TAL。但是，SB-334867-A（6杯/ 1毫升）在三个采集阶段中，隔天提供与糖精（CS +）相关的​​风味，而没有糖精（CS-）的不同风味时，阻止了口味偏好学习。这些结果提供了食欲系统与味觉学习之间关系的证据。他们初步提出内源性食欲肽和味觉和去味（内脏和口腔）信号在与习得味觉有关的大脑区域会聚的可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号