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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice.
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Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice.

机译：选择性5-羟色胺再摄取抑制剂的急性焦虑样作用被苯二氮卓地西epa在BALB / c小鼠中减弱。

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摘要

Selective serotonin re-uptake inhibitors (SSRIs), which are used commonly to treat anxiety disorders, have characteristic anxiogenic effects following acute administration. Treatment with anxiolytic benzodiazepines (BZs) may reduce these effects, although little is known about potential drug interactions. Our study evaluated acute anxiogenic-like effects of SSRIs, alone and combined with a BZ. Adult male BALB/c mice received fluoxetine (3.0-30.0mg/kg, i.p.) or citalopram (3.0-30.0mg/kg, i.p.) alone or in combination with diazepam (0.3-10.0mg/kg, i.p.), after which they were evaluated with the light/dark and open-field tests for anxiogenesis/anxiolysis. In addition, release of the stress hormone corticosterone was assessed following combined SSRI/BZ administration. In the light/dark and open-field tests, acute SSRIs produced a behavioral profile consistent with anxiogenesis, while diazepam produced an anxiolytic-like profile. Pre-treatment with diazepam (0.3-10mg/kg) reversed the effects of an anxiogenic-like dose of an SSRI (18mg/kg fluoxetine, 30mg/kg citalopram) in both light/dark and open-field tests. Diazepam, fluoxetine or citalopram, and their combination all significantly increased plasma corticosterone levels to the same degree. These findings suggest that a BZ-type drug can attenuate acute anxiogenic-like effects of an SSRI via a mechanism independent of corticosterone regulation.
机译：选择性5-羟色胺再摄取抑制剂（SSRIs）通常用于治疗焦虑症，急性给药后具有特征性的焦虑作用。尽管对潜在的药物相互作用知之甚少，但用抗焦虑的苯二氮卓类药物（BZs）治疗可能会降低这些作用。我们的研究评估了单独和与BZ联合使用时SSRIs的急性焦虑样作用。成年雄性BALB / c小鼠单独或与地西epa（0.3-10.0mg / kg，ip）联合接受氟西汀（3.0-30.0mg / kg，ip）或西酞普兰（3.0-30.0mg / kg，ip），然后用明/暗和开放视野测试评估血管生成/抗焦虑作用。另外，在联合SSRI / BZ给药后评估了应激激素皮质酮的释放。在明/暗和开放视野测试中，急性SSRI产生的行为特征与血管生成一致，而地西epa产生类似抗焦虑药的特征。用地西epa（0.3-10mg / kg）进行的预处理在明/暗和明场试验中均会逆转类似焦虑的SSRI（18mg / kg氟西汀，30mg / kg西酞普兰）的作用。地西p，氟西汀或西酞普兰及其组合均显着增加血浆皮质酮水平至相同程度。这些发现表明，BZ型药物可以通过独立于皮质类固醇调节的机制来减轻SSRI的急性焦虑症样作用。

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