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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats
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The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats

机译：多巴胺受体拮抗剂左旋四氢巴马汀减弱海洛因的自我给药和海洛因诱导的大鼠恢复作用

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摘要

Opiate addiction is a chronic recrudescent disorder characterized by a high rate of relapse. Levo-tetrahydropalmatine (l-THP) is an alkaloid substance extracted from Corydalis and Stephania and is contained in a number of traditional Chinese herbal preparations. Compared to other dopamine receptor antagonists, l-THP has lower affinity for D2 receptors than for D1 receptors, and a recent study showed that l-THP also binds to D3 receptors, possibly functioning as an antagonist. The unique pharmacological profile of l-THP suggests that l-THP may be effective for the treatment of opiate addiction. In this study, we investigated the effects of l-THP on heroin self-administration and reinstatement triggered by a priming injection of heroin in abstinent rats trained to stably self-administer heroin under an extinction/reinstatement protocol, and found that l-THP (2.5 and 5 mg/kg, i.p.) decreased heroin self-administration on the fixed-ratio 1 schedule and dose-dependently (1.25, 2.5 and 5 mg/kg, i.p.) inhibited heroin-induced reinstatement of heroin-seeking behavior. Importantly, l-THP (1.25 and 2.5 mg/kg, i.p.) did not affect locomotion, indicating that the observed effects of l-THP on reinstatement do not appear to be due to motor impairments. The present results demonstrated that dopamine receptor antagonist l-THP attenuates heroin self-administration and heroin-induced reinstatement.
机译：阿片成瘾是一种以高复发率为特征的慢性复发性疾病。左旋四氢巴马汀（1-THP）是从延胡索和Stephania中提取的一种生物碱物质，并包含在许多传统中草药制剂中。与其他多巴胺受体拮抗剂相比，l-THP对D2受体的亲和力比对D1受体的亲和力低，最近的一项研究表明，l-THP也与D3受体结合，可能起拮抗剂的作用。 L-THP的独特药理学特征表明L-THP可能有效治疗阿片成瘾。在这项研究中，我们研究了l-THP对在灭绝/恢复协议下训练的稳定自食海洛因的戒酒大鼠中海洛因初次注射引发的海洛因自我管理和恢复的影响，并发现l-THP（ 2.5和5 mg / kg，ip）以固定比例1的时间表减少海洛因的自我给药，并且剂量依赖性（1.25、2.5和5 mg / kg，ip）抑制海洛因诱导的海洛因寻求行为的恢复。重要的是，l-THP（1.25和2.5 mg / kg，腹膜内）不影响运动，这表明所观察到的l-THP对恢复的作用似乎不是由于运动障碍引起的。目前的结果表明，多巴胺受体拮抗剂1-THP减弱了海洛因的自我给药和海洛因诱导的恢复。

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