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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reversal of caffeine withdrawal by ingestion of a soft beverage.
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Reversal of caffeine withdrawal by ingestion of a soft beverage.

机译：摄入软饮料可逆转咖啡因的摄入。

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Followlng regular use, acute cessation of caffeine is associated with a characteristic withdrawal syndrome. Despite this, caffeine remains popular with its consumers. The aim of this study was to examine the physiologic and psychologic effects of small caffeine doses, administered in the form of a market-leading soft drink, on healthy women who were acutely withdrawn from caffeine. After 48-h abstinence and overnight fast, 11 healthy (22 to 40 years) female volunteers, all regular caffeine users (daily consumption 143 to 773 mg) consumed using a double-blind. randomized, controlled cross-over design either 2 tins of regular or caffeine-free Diet Coke. On both visits a Mars bar was eaten to prevent hypoglycaemia. Thus, the caffeine load was 76 or 10 mg respectively. Following ingestion of regular Diet Coke, there was a l0% fall in middle cerebral artery velocity (95% CI [6%-l4%], p < 0.005 versus caffeine free) and improvement in feelings of pleasure (p < 0.046) and energy (p < 0.037). Intellectual function (4-choice reaction time) was unaffected by caffeine status. On both visits, ingestion of Diet Coke induced a pressor response (maximum rise in systolic pressure +15+/- 2 mm Hg with caffeine and +l2 +/- 2 mm Hg with caffeine-free beverage, both p < 0.001 compared with baseline). In conclusion, in women acutely withdrawn from caffeine, ingestion of a popular soft beverage containing modest amounts of caffeine is associated with demonstrable physiologic and psychologic effects.
机译：在常规使用后，咖啡因的急性戒断与典型的戒断综合征相关。尽管如此，咖啡因仍然受到消费者的欢迎。这项研究的目的是研究以市场领先的软饮料形式服用的小剂量咖啡因对从咖啡因中急性退出的健康女性的生理和心理影响。在禁食48小时和禁食过夜后，有11位健康的（22至40岁）女性志愿者自愿使用咖啡因（每天服用143到773 mg）来进行双盲服用。 2罐普通或不含咖啡因的健怡可乐的随机，受控交叉设计。在两次探访中，都吃了火星酒吧以预防低血糖症。因此，咖啡因负荷分别为76或10mg。摄入常规饮食可乐后，大脑中动脉速度下降了10％（95％CI [6％-l4％]，与不含咖啡因的情况相比，p <0.005），愉悦感（p <0.046）和精力得到改善（p <0.037）。咖啡因状态不会影响智力功能（4-选择反应时间）。在两次就诊中，摄入健怡可乐都会引起升压反应（咖啡因的收缩压最大升高+15 +/- 2 mm Hg，不含咖啡因的饮料收缩压最大升高+ l2 +/- 2 mm Hg，与基线相比均p <0.001 ）。总之，在急性退出咖啡因的妇女中，摄入含有适量咖啡因的受欢迎的软饮料与明显的生理和心理影响有关。

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