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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Rotational behavior in dopamine nigrostriatal denervated rats: effects of a wide range of time intervals between apomorphine administrations.
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Rotational behavior in dopamine nigrostriatal denervated rats: effects of a wide range of time intervals between apomorphine administrations.

机译：多巴胺黑纹状体失神经大鼠的旋转行为：阿扑吗啡给药之间很宽的时间间隔的影响。

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Previous studies using the turning behavior animal model have shown both increases and decreases in rotational behavior following successive administrations of dopamine agonists. To clarify the results obtained with this model, we studied the variability of rotational behavior after repeated challenges with low doses of apomorphine (0.05 mg/kg) at different time intervals ranging between 2 h and 14 days. Results show a decrease in the total number of turns with time intervals of 2, 6, and 12 h between administrations, and an increase in the total number of turns when apomorphine was administered once every 24 h. In contrast, when animals were tested at 7- and 14-day intervals, a stable number of turns in successive challenges was obtained. These results suggest that when successive injections of dopamine agonists are administered at sufficiently long intervals of time, the neuroadaptations that take place due to repeated drug exposure may not be apparent. These findings are relevant for the design of future experiments using this model.
机译：先前使用转弯行为动物模型进行的研究表明，连续服用多巴胺激动剂后，旋转行为既增加又减少。为了阐明使用该模型获得的结果，我们研究了在低剂量的阿扑吗啡（0.05 mg / kg），2 h和14天的不同时间间隔反复挑战后的旋转行为变异性。结果显示，两次给药之间的间隔时间分别为2、6和12 h，总转数减少，而每24 h一次给予阿扑吗啡时，总转数增加。相反，以7天和14天的间隔对动物进行测试时，在连续挑战中获得了稳定的转数。这些结果表明，在足够长的时间间隔内连续注射多巴胺激动剂时，由于反复接触药物而引起的神经适应可能并不明显。这些发现与使用该模型的未来实验设计有关。

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