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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Altering dietary levels of protein or vitamins and minerals does not modify morphine-induced analgesia in male rats.
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Altering dietary levels of protein or vitamins and minerals does not modify morphine-induced analgesia in male rats.

机译：饮食中蛋白质，维生素和矿物质含量的改变不会改变吗啡引起的雄性大鼠的镇痛作用。

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Previous research has demonstrated that chronic intake of nutritive sweet solutions, but not nonnutritive sweet solutions, enhances morphine's analgesic potency. To separate out the effects of sweet taste from other changes in dietary intake, which result when rats consume a sucrose solution, the effects of altering dietary levels of protein, or vitamins and minerals on morphine-induced analgesia were examined. In Experiment 1, 40 male Long-Evans rats were fed standard chow or a semipurified diet containing either 10, 20, or 40% protein. Three weeks later, antinociceptive responses to morphine were examined using the tail flick procedure. Tail flick latencies were measured immediately prior to and 30, 60, and 90 min after the administration of morphine sulfate (0.0, 1.25, 2.5, and 5.0 mg/kg, SC). At all three measurement times, antinociceptive responses increased directly as a function of the dose of morphine, but did not differ as a function of diet. In Experiment 2, 24 rats were maintained on either standard laboratory chow or semipurified diets containing 20% protein and either 100% or 25% of the recommended levels of vitamins and minerals for 3 weeks. Tail flick latencies were measured immediately prior to and 30 min after injections (SC) of 2.5 mg/kg morphine sulfate. This procedure was repeated until a cumulative dose of 10.0 mg/kg was obtained. Tail flick latencies increased significantly as a function of drug dose, but did not differ across dietary conditions. These results demonstrate that the increase in morphine-induced analgesia seen in rats consuming a sucrose solution is not due to alterations in either protein or micronutrient intake.
机译：先前的研究表明，长期摄入营养性甜味剂而非非营养性甜味剂可增强吗啡的止痛效果。为了将甜味的影响与其他饮食摄入的变化（当大鼠食用蔗糖溶液时产生的影响）分开，我们研究了饮食中蛋白质，维生素和矿物质的饮食水平变化对吗啡诱导的镇痛的影响。在实验1中，对40只雄性Long-Evans大鼠进行了标准饮食或半纯化饮食，其中含有10％，20％或40％的蛋白质。三周后，使用甩尾法检查了对吗啡的镇痛反应。在施用硫酸吗啡（0.0、1.25、2.5和5.0 mg / kg，SC）之前和之后30、60和90分钟测量尾甩潜伏期。在所有三个测量时间，抗伤害感受反应均随吗啡剂量的增加而直接增加，但随饮食的变化却没有差异。在实验2中，将24只大鼠维持在标准实验室食物或半纯正饮食中，其中饮食中含有20％的蛋白质以及100％或25％的维生素和矿物质的推荐水平。在注射（SC）2.5 mg / kg硫酸吗啡之前和之后30分钟测量尾甩潜伏期。重复该过程，直到累积剂量为10.0 mg / kg。尾甩潜伏期随着药物剂量的增加而显着增加，但在饮食条件上没有差异。这些结果表明，在食用蔗糖溶液的大鼠中看到的吗啡诱导的镇痛作用的增加并非由于蛋白质或微量营养素摄入的改变。

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