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首页> 外文期刊>Pharmaceutical Biology >Evaluation of antidiarrheal and in vitro antiprotozoal activities of extracts of leaves of Alocasia indica.
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Evaluation of antidiarrheal and in vitro antiprotozoal activities of extracts of leaves of Alocasia indica.

机译：海芋叶片提取物的止泻和体外抗原生动物活性评估。

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CONTEXT: Alocasia indica Schott (Araceae) is used in several regions of India, especially in rural communities, by traditional medicine practitioners to treat diarrhea. However, no scientific data are available to justify the traditional potentials of the plant species in gastrointestinal disorders. OBJECTIVE: To evaluate the antidiarrheal and in vitro antiprotozoal activities of extracts of leaves of Alocasia indica using various pharmacological models. MATERIALS AND METHODS: In vitro antidiarrheal activity of aqueous and ethanol extracts of Alocasia indica was evaluated against Escherichia coli, Salmonella typhimurium, Shigella flexneri and Staphylococcus aureus by agar well diffusion method. In vivo antidiarrheal activity of the extracts was studied against recinolic acid-induced diarrhea and magnesium sulfate-induced diarrhea. The effect of the extracts on normal intestinal transit, recinolic acid-induced intestinal transit, recinolic acid-induced intestinal fluid accumulation (enteropooling) and gastric emptying was assessed. In vitro antiprotozoal activity of aqueous and ethanol extracts of Alocasia indica was studied against Entamoeba histolytica and Giardia intestinalis. RESULTS: The aqueous and ethanol extracts exhibited significant in vitro antidiarrheal activity compared to the standard drug ciprofloxacine (10 microg/mL). The plant extracts showed significant (P <0.05) and dose-dependent antidiarrheal activity comparable to that of the reference drug, loperamide (10 mg/kg). The plant extracts exhibited significant in vitro antiprotozoal activity against both protozoa compared to the standard amebicidal and giardicidal drugs, metronidazole and emetine. DISCUSSION AND CONCLUSION: The results showed that the extracts of Alocasia indica have significant antidiarrheal and in vitro antiprotozoal activities which support its use in traditional herbal medicine practice.
机译：语境：印度洋地区的loc螺（天南星科）在印度的一些地区，特别是在农村社区，被传统医学从业者用来治疗腹泻。然而，没有科学数据可证明该植物物种在胃肠道疾病中的传统潜力。目的：采用多种药理模型评价海芋叶片提取物的抗腹泻和体外抗原生动物活性。材料与方法：采用琼脂微孔扩散法评价了海芋的水和乙醇提取物对大肠杆菌，鼠伤寒沙门氏菌，弗氏志贺氏菌和金黄色葡萄球菌的体外止泻活性。研究了提取物的体内抗腹泻活性，以对抗环酸引起的腹泻和硫酸镁引起的腹泻。评估了提取物对正常肠运输，阿魏酸诱导的肠运输，阿魏酸诱导的肠液积聚（肠沉积）和胃排空的影响。研究了海芋的水提物和乙醇提取物对解组织变形虫和肠贾第虫的体外抗原生动物活性。结果：与标准药物环丙沙星（10微克/毫升）相比，水提取物和乙醇提取物具有显着的体外止泻活性。植物提取物显示出与参考药物洛哌丁胺（10毫克/千克）相当的显着（P <0.05）和剂量依赖性的止泻活性。与标准杀虫药和杀虫药，甲硝唑和曲美汀相比，植物提取物对两种原生动物均表现出显着的体外抗原生动物活性。讨论与结论：结果表明，海芋的提取物具有显着的止泻和体外抗原生动物活性，这支持其在传统草药实践中的使用。

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