• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmaceutical Biology >Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of Leucenia leucocephala.
【24h】

Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of Leucenia leucocephala.

机译：从白花Leucenia leucocephala叶片中分离的多酚类化合物的抗氧化和细胞毒性活性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CONTEXT: Cancer is a serious clinical problem to the health care system. Anticancer drugs have been extracted from plants containing phenolic compounds. Leucenia species (Fabaceae) contain a variety of bioactive components of numerous biological and pharmacological properties. OBJECTIVE: This study explored the constitutive polyphenols of Leucenia leucocephala Lam. growing in Egypt and evaluated the antioxidant and cytotoxic activity. MATERIALS AND METHODS: Chemical structures of the isolated compounds from the leaves of L. leucocephala were established by spectral techniques (UV, (1)H, and (13)C NMR, MS). RESULTS: Chromatographic separation of 80% MeOH extract of the leaves of L. leucocephala have resulted in a novel flavonoid-galloyl glycoside [myricetin 3-O-(2',3'4'-tri-O-galloyl)-alpha-L-rhamnopyranoside] with three known polyphenolic compounds isolated for the first time from this species (apigenin 7-O-beta-D-glucuronopyranoside methyl ester, luteolin 7-O-beta-D-glucuronopyranoside methyl ester, and 1,3,6-tri-O-galloyl-beta-D-glucopyranose) and seven known previously isolated compounds. Also, 80% methanol extract exhibited high antioxidant activity (SC(50) = 3.94 microg/ml), which is correlated with its phenolic content. The extract also showed cytotoxic activity against Hep G2 (IC(50) value 1.41 microg/ml) confirming its anticancer activity against hepatocellular carcinoma. Among the tested compounds (4-8) for antioxidant property, compound 7 was the most active compound (SC(50) = 2.49 microg/ml). Also compounds 7 and 8 exhibited high cytotoxic activity (IC(50) = 2.41 and 2.81 microg/ml, respectively). DISCUSSION AND CONCLUSION: These findings demonstrate that the leaves of L. leucocephala contain a considerable amount of polyphenolic compounds with high antioxidant properties, thus it has great potential as a source for natural health products.
机译：背景：癌症是卫生保健系统的严重临床问题。已从含有酚类化合物的植物中提取抗癌药。芥属物种（豆科）包含具有许多生物学和药理特性的多种生物活性成分。目的：本研究探索了白花榄仁的组成型多酚。在埃及生长并评估了抗氧化和细胞毒性活性。材料与方法：通过光谱技术（UV，（1）H和（13）C NMR，MS）建立了从白头翁叶中分离得到的化合物的化学结构。结果：白头翁叶的80％MeOH提取物的色谱分离产生了一种新的类黄酮-半乳糖苷[杨梅素3-O-（2'，3'4'-tri-O-galloyl）-alpha-L -鼠李吡喃糖苷]，并首次从该物种中分离出三种已知的多酚化合物（芹菜素7-O-β-D-葡糖醛酸吡喃糖苷甲酯，木犀草素7-O-β-D-葡糖醛酸吡喃糖苷甲酯和1,3,6-三-O-galloyl-β-D-吡喃葡萄糖）和七个已知的先前分离的化合物。同样，80％的甲醇提取物表现出高的抗氧化活性（SC（50）= 3.94 microg / ml），这与其酚含量有关。该提取物还显示出对Hep G2的细胞毒活性（IC（50）值为1.41 microg / ml），证实了其对肝细胞癌的抗癌活性。在测试的化合物（4-8）的抗氧化性能中，化合物7是活性最高的化合物（SC（50）= 2.49 microg / ml）。化合物7和8也显示出高的细胞毒性活性（IC（50）分别为2.41和2.81 microg / ml）。讨论与结论：这些发现表明白头参叶中含有大量具有高抗氧化特性的多酚类化合物，因此它具有作为天然保健品来源的巨大潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号