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Synthesis and Fungitoxicity of 1-(3-(Benzylideneamino)phenyl) Ethanone and its C-Phenyl Derivatives

机译:1-(3-(苯甲叉基氨基)苯基)乙酮及其C-苯基衍生物的合成及杀真菌作用

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摘要

1-(3-(Benzylideneamino)phenyl)ethanone and its C-phenyl derivatives (Ia-VIIa) were synthesized by condensing 1-(3-aminophenyl)ethanone with aryl aldehydes (I-VII). The products were characterized on the basis of elemental analysis and spectral data and were screened in vitro for fungitoxicity against Alternaria alternata, Fusarium oxysporum, Helminthosporium oryzae and Colletotrichum capsici by spore germination inhibition technique. 1-(3-(4-Hydroxy-3-methoxybenzylideneamino)phenyl)ethanone (VIa) possessed ED_(50) value of 8 μg/ml against F. oxysporum which was comparable with that of standard fungicide Bavistin 50 WP whereas compounds 1-(3-(3,4-dimethoxybenzylideneamino)phenyl)ethanone (IIIa) and 1-3-(3,4,5-trimethoxybenzylideneamino)phenyl)ethanone (Va) had ED_(50) value of 40 μg/ml each against H. oryzae which was found to be lower than that of standard fungicide Indofil M-45 (46 μg/ml).
机译:通过将1-(3-氨基苯基)乙酮与芳基醛(I-VII)缩合来合成1-(3-(亚苄基氨基)苯基)乙酮及其C-苯基衍生物(Ia-VIIa)。根据元素分析和光谱数据对产物进行表征,并通过孢子萌发抑制技术体外筛选其对链格孢菌,尖孢镰刀菌,稻瘟病菌和辣椒炭疽菌的真菌毒性。 1-(3-(4-羟基-3-甲氧基苄叉亚氨基)苯基)乙酮(VIa)对oxy F. oxysporum的ED_(50)值为8μg/ ml,与标准杀菌剂Bavistin 50 WP相当,而化合物1- (3-(3,4-二甲氧基亚苄基氨基)苯基)乙酮(IIIa)和1-3-(3,4,5-三甲氧基亚苄基氨基)苯基)乙酮(Va)对H的ED_(50)值分别为40μg/ ml发现米曲霉比标准杀真菌剂Indofil M-45(46μg/ ml)低。

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