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Biochemical Mode of Action of Bromophos on Bombyx mori L.

机译：溴磷对家蚕的生化作用模式

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摘要

The biochemical action of bromophos, an organophosphorus insecticide with relatively low toxicity to the silkworm, was studied on Bombyx mori. Acetylcholinesterase activity in the IV instar larvae shows differential tissue distribution, being highest in the integument followed by the gut and lowest in the haemolymph. In vivo inhibition of acetylcholinesterase by topical application of bromophos to the IV instar larvae was observed. The inhibition recovered rapidly within 12 h. The inhibition was dose-related. In vitro inhibition studies showed that cholinesterase of the gut is more sensitive to bromophos than that of the integument enzyme as judged by IC_(50) values. The parent phosphorothioate compound is by itself a good inhibitor of cholinesterase.
机译：在家蚕上研究了对家蚕毒性相对较低的有机磷杀虫剂溴磷的生化作用。 IV龄幼虫中的乙酰胆碱酯酶活性显示出不同的组织分布，在被膜中最高，其次是肠，在血淋巴中最低。观察到通过将溴磷局部施用到IV龄幼虫体内抑制乙酰胆碱酯酶。抑制作用在12小时内迅速恢复。抑制作用与剂量有关。体外抑制研究表明，根据IC_（50）值判断，肠道胆碱酯酶对溴化磷的敏感性要比被膜酶高。母体硫代磷酸酯化合物本身就是胆碱酯酶的良好抑制剂。

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