Based on the fractional approach previously developed by our group in the framework of the Miertus-Scrocco-Tomasi self-consistent reaction field method,we explore herde the suitability of 'solvation' and 'transfer' dipoles to describe the topological distribution of hydrophilic/hydrophobic properties of molecules.Both descriptors provide a simplified but yet accurate representation of the 3D distribution of hydrophilic and hydrophobic areas in molecules,which can be valuable in structure-activity relationship and nolecular-field alignment studies.
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