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首页> 外文期刊>Physiological Research >Collagen Synthesis, Nitric Oxide and Asymmetric Dimethylarginine in Diabetic Subjects Undergoing Hyperbaric Oxygen Therapy
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Collagen Synthesis, Nitric Oxide and Asymmetric Dimethylarginine in Diabetic Subjects Undergoing Hyperbaric Oxygen Therapy

机译：接受高压氧治疗的糖尿病患者的胶原蛋白合成，一氧化氮和不对称二甲基精氨酸

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The main pathological condition in patients with impaired wound healing is diabetes mellitus. These patients have significantly low circulating nitric oxide (NO) levels because the stimulatory action of insulin on NO synthesis is absent. Additionally, asymmetric dimethylarginine (ADMA), an inhibitor of NO synthase, is increased owing to the generation of oxidative stress. NO was thought to contribute to wound healing. Hyperbaric oxygen (HBO) treatment is generally used in order to accelerate the healing of wounds. The aim of this study was to determine the changes in plasma procollagen type I and III N-terminal peptides (PINP and PIIINP), total nitriteitrate (NOx) and ADMA levels; and to evaluate their relation to healing during the HBO treatment of foot ulcers. Data obtained from 18 diabetic patients before and after the HBO therapy were compared statistically by the Wilcoxon test. NOx was increased in 11 and ADMA was decreased in 12 patients following HBO treatment. Both PINP (32.6±29.4 μg/l vs 44.3±33.4μg/l) and PIIINP (6.97±3.01 μg/l vs 7.92±2.49 μg/l) were significantly increased (p<0.05). Progressive reductions were observed in wound areas, as assessed by the digital wound imaging. In 12 patients, wounds healed by 50 % or higher; whereas only two subjects had minimal improvements (15 % or less healing). The duration of diabetes correlated negatively with wound healing (r = -498, p<0.05). This study suggests that increased collagen synthesis is associated with wound healing during hyperbaric oxygen therapy.
机译：伤口愈合不良的患者的主要病理状况是糖尿病。这些患者的循环一氧化氮（NO）水平明显较低，因为没有胰岛素对NO合成的刺激作用。另外，由于氧化应激的产生，NO合酶的抑制剂不对称二甲基精氨酸（ADMA）增加。没有被认为有助于伤口愈合。通常使用高压氧（HBO）治疗以加速伤口的愈合。这项研究的目的是确定I型和III型血浆胶原蛋白N端肽（PINP和PIIINP），亚硝酸盐/硝酸盐总量（NOx）和ADMA水平的变化。并评估它们在HBO治疗足部溃疡过程中与愈合的关系。通过Wilcoxon检验对从HBO治疗前后的18位糖尿病患者获得的数据进行统计学比较。 HBO治疗后11例患者的NOx升高，而ADMA降低12例。 PINP（32.6±29.4μg/ l与44.3±33.4μg/ l）和PIIINP（6.97±3.01μg/ l与7.92±2.49μg/ l）均显着增加（p <0.05）。通过数字伤口成像评估，伤口区域逐渐减少。在12例患者中，伤口愈合了50％或更高;而只有两个对象的改善很小（治愈率不超过15％）。糖尿病的持续时间与伤口愈合呈负相关（r = -498，p <0.05）。这项研究表明，高压氧治疗过程中胶原蛋白合成与伤口愈合有关。

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