首页> 美国政府科技报告 >Selective Reductions: 40. A Critical Examination of the relative Effectiveness of Various Reducing Agents for the Asymmetric Reduction of Different Classes of Ketones

【24h】

Selective Reductions: 40. A Critical Examination of the relative Effectiveness of Various Reducing Agents for the Asymmetric Reduction of Different Classes of Ketones

机译：选择性减少：40。对各种还原剂对不同类别酮的不对称还原的相对有效性的批判性考察

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Among a wide variety of highly promising asymmetric reducing agents recently reported in the literature, 20 promising reagents were selected for critical examination. All of the data for the asymmetric reductions of prochiral ketones by these 20 reagents were compiled. The various ketones were organized into 10 distinct classes. However, direct comparisons of the relative effectiveness of these 20 reagents for individual classes of ketones proved not possible because of the wide variation in the individual ketones used to test each reagent. In the hope of making possible such comparison, we selected one representative ketone for each of the 10 different classes of ketones. Then, six of the most promising reagents were selected: B-isopinocampheyl-9-borabicyclo 3.3.1 nonane, B-Ipc-9-BBN (neat); diisopinocampheylchloroborane, Ipc2BC1; a mixed reagent of 2 equiv of BH3 with (S)-(-)-2-amino-3- methyl-1, 1-diphenylbutan-1-ol, BH3-AMDPB(2:1); NB-Enantride; K-Glucoride; and Binal-H. These six reagents were applied to the 10 selected standard ketones. On the basis of results obtained for the six reagents and the 10 selected ketones, preferred reagents are suggested for the asymmetric reduction of individual classes of ketones.

著录项

作者
Brown, H. C.; Park, W. S.; Cho, B. T.; Ramachandran, P. V.;
展开▼
作者单位

展开▼
年度 1987
页码 p.1-9
总页数 9
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Chemical agents; Ketones; Reduction(Chemistry); Asymmetry; Reprints;

机译：化学试剂;酮;还原（化学）;不对称;重印;

相似文献

外文文献
中文文献
专利

1. New chiral borohydride based reducing agent: Asymmetric reduction of 9-anthryl trifluoromethyl ketone and other carbonyl compounds [J] . Maiti DK., Bhattacharya PK. Synthetic Communications . 1998,第1期

机译：新的基于手性硼氢化物的还原剂：9-蒽三氟甲基酮和其他羰基化合物的不对称还原
2. Butyltriphenylphosphonium tetraborate (BTPPTB) as a selective reducing agent for thereduction of imines,enamines and oximes and reductive alkylation of aldehdyes or ketones with primary amines in methanol or under solid-phase conditions [J] . Abdol Reza Hajipour, Mohammadreza Noroallhi, Iraj Mohammadpoor-Baltork Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2001,第2期

机译：四硼酸三苯基丁酯（BTPPTB）作为选择性还原剂，用于在甲醇中或在固相条件下还原亚胺，烯胺和肟，并与伯胺还原醛或酮的烷基化反应
3. Benzyltriphenylphosphonium tetraborate (BTPPTB) as a selective reducing agent for reduction of aldehydes and ketones to the corresponding alcohols [J] . Hajipour AR., Najafi AR., Mallakpour SE. Phosphorus, Sulfur, and Silicon and the Related Elements . 2000,第0期

机译：苄基三苯基四硼酸（（BTPPTB）作为选择性还原剂，用于将醛和酮还原为相应的醇
4. Experiment and Mechanism Analysis of Selective Non-Catalytic Reduction with the Compound Reducing Agents in a Lab-scale CFB Reactor [C] . Jiancong Dong, Degui Bi, Tuo Zhou Annual International Conference on Material Engineering and Application . 2019

机译：用实验室CFB反应器中复合还原剂的选择性非催化还原的实验与机理分析
5. Characterization and reaction mechanism for the selective catalytic reduction of nitrogen oxides using natural and copper modified clay catalysts with ammonia as a reducing agent. [D] . Corral-Avitia, Alba Yadira. 2001

机译：使用天然和铜改性的粘土催化剂，以氨为还原剂，选择性催化还原氮氧化物的表征和反应机理。
6. Evaluation of the effectiveness of neuromuscular training to reduce anterior cruciate ligament injury in female athletes: a critical review of relative risk reduction and numbers-needed-to-treat analyses [O] . Dai Sugimoto, Gregory D. Myer, Jennifer M. McKeon, -1

机译：神经肌肉训练的效果评价以减少在女运动员前交叉韧带损伤：相对危险度降低和分析需要性治疗数-的严格审查
7. ASYMMETRIC REDUCTION OF PROCHIRAL KETONES WITH A CHIRAL REDUCING AGENT PREPARED FROM STANNOUS CHLORIDE, CHIRAL DIAMINE AS A LIGAND, AND DIISOBUTYLALUMINUM HYDRIDE [O] . Takeshi Oriyama, Teruaki Mukaiyama 1984

机译：具有由氯化锡，手性胺作为配体制备的手性还原剂的前三丙酮的不对称还原，以及二异丁基铝氢化物
8. Selective Reductions. 45. Asymmetric Reduction of Prochiral Ketones by Iso-2-methyl, Iso-2-Ethyl, and (Iso-2(2-(Benzyloxy)Ethyl)Apopinocampheyl)-tert-Butylchloroboranes. Evidence for a Major Influence of the Steric Requirements of the 2-Substituent on the Efficiency of Asymmetric Reduction. [R] . Brown, H. C., Ramachandran, P. V. 1989

机译：选择性减少。 45.异-2-甲基，异-2-乙基和（异-2（2-（苄氧基）乙基）apopinocampheyl） - 叔丁基氯硼烷不对称还原前手性酮。 2-取代基的空间要求对不对称还原效率的主要影响的证据。

Selective Reductions: 40. A Critical Examination of the relative Effectiveness of Various Reducing Agents for the Asymmetric Reduction of Different Classes of Ketones

摘要

著录项

相似文献

相关主题

期刊订阅