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Broad Spectrum Chemotherapy: A Novel Approach Using Beta-Galactosidase Activated Pro-Drugs

机译：广谱化疗：使用β-半乳糖苷酶激活的前药的新方法

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Gene therapy shows promise for treating prostate cancer and is being exploited in several clinical trials. A major hurdle is establishing a method of verifying transgene activity in situ. Beta-galactosidase (beta-gal) was historically the most popular reporter gene for molecular biology. I have introduced a novel concept for further exploration of gene therapy using beta- galactosidase to activate a broad-spectrum chemotherapeutic to assess the efficacy of the pro-drugs in vitro and explore growth delay in animal models. I also have developed a new beta- galactosidase molecular reporter for MRI spectra, which can be used to detection of lacZ gene expression in vivo.

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作者
Liu, L.;
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年度 2007
页码 1-30
总页数 30
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Drugs; Chemotherapy; Prostate cancer; Magnetic resonance imaging; Clinical trials; Detection; Growth(General); Enzymes; Gene therapy; Delay; Galactose; In vivo analysis; Molecular biology; Genes; Animals;

机译：药物;化疗;前列腺癌;磁共振成像;临床试验;检测;生长（一般）;酶;基因治疗;延迟;半乳糖;体内分析;分子生物学;基因;动物;

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专利

1. 缺氧激活前药evofosfamide(TH-302)在体内和体外对鼻咽癌的疗效 [J] . Yan Huang, Ying Tian, Yuanyuan Zhao, 癌症（英文版） . 2018,第012期
2. The hypoxia activated pro-drug evofosfamide exhibits tumour suppressive activity and synergy with chemotherapy against primary and metastatic breast cancers [J] . Liapis Vasilios, Zinonos Irene, Labrinidis Agatha, International journal of molecular medicine . 2017,第Suppla1期

机译：缺氧活化的促药Evofosfamide含有肿瘤抑制活性和对原发性和转移性乳腺癌的化疗的协同作用
3. Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma [J] . Liapis Vasilios, Labrinidis Agatha, Zinonos Irene, Cancer letters . 2015,第1期

机译：缺氧激活的前药TH-302具有强大的抑癌活性，并与化学疗法协同治疗骨肉瘤
4. Activity of the hypoxia-activated pro-drug TH-302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy [J] . SaggarJ.K., TannockI.F. International Journal of Cancer =: Journal International du Cancer . 2014,第11期

机译：缺氧激活的前药TH-302在实体瘤缺氧和血管周围区域的活性及其增强化疗疗效的潜力
5. Investigation of Cu- and Zn-based Impregnated Activated Carbons for use in Broad Spectrum Gas Mask Applications [C] . J.W.H. Smith, J. V. Romero, K. Dunphy, World Conference on Carbon . 2012

机译：用于广谱气体掩模应用的Cu-和Zn浸渍活性碳的研究
6. Broad-spectrum protection against chemotherapy-induced alopecia by acidic and basic fibroblast growth factors. [D] . Wang, Jie. 2005

机译：酸性和碱性成纤维细胞生长因子对化疗引起的脱发的广谱保护。
7. HYPOXIA-ACTIVATED PRO-DRUG TH-302 EXHIBITS POTENT TUMOUR SUPPRESSIVE ACTIVITY AND COOPERATES WITH CHEMOTHERAPY AGAINST OSTEOSARCOMA [O] . Vasilios Liapis, Agatha Labrinidis, Irene Zinonos, -1

机译：缺氧激活的前药TH-302表现出强大的肿瘤抑制活性并与化学疗法合作治疗骨肉瘤
8. Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma [O] . Liapis, V., Labrinidis, A., Zinonos, I., 2015

机译：缺氧激活的前药TH-302表现出有效的肿瘤抑制活性，并与化疗对抗骨肉瘤

Broad Spectrum Chemotherapy: A Novel Approach Using Beta-Galactosidase Activated Pro-Drugs

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