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首页> 美国政府科技报告 >Role of Cyclin E and Its Lower Molecular Forms in the Oncogenesis of Ovarian Cancer and Its Predictive Value in Patients with Early Stage Ovarian Tumor
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Role of Cyclin E and Its Lower Molecular Forms in the Oncogenesis of Ovarian Cancer and Its Predictive Value in Patients with Early Stage Ovarian Tumor

机译：Cyclin E及其低分子形式在早期卵巢肿瘤患者卵巢癌发生中的作用及其预测价值

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The deregulation of cell cycle checkpoints, with loss of regulation at the G1/S transition, has been shown to play an important role in the transformation to a malignant phenotype. Our studies have focused on cyclin E, which appears in late GI and flanks the restriction point. We hypothesize that alterations of cyclin E in ovarian cancer cells contributes to the oncogenesis of ovarian tumors and negatively impacts outcome in patients with Stage I-III cancer. In this proposal we will (1) develop a comprehensive ovarian cell line model for characterization of the role of cyclin E in ovarian cancer, (2) delineate the role of cyclin E and its tumor specific LMW forms in the development of malignant phenotype in vitro and in nude mice. (3) establish the prognostic value of the hyperactive forms of cyclin E in patients with Stage I-III ovarian cancer and (4) examine the biochemical significance of the LMW forms of cyclin E in tumor specimens. The results from our studies will provide much needed information about the molecular biology of ovarian carcinoma and may open new avenues for the development of targeted therapies.

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