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首页> 美国政府科技报告 >Test of Carcinogenicity in Mouse Skin: Methylenedianiline, gamma Glycidyloxytrimethyloxysilane, gamma Aminopropyltriethoxysilane and a Mixture of M-Phenylenediamine, Methylenedianiline, and Diglycidylether of Bisphenol-A
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Test of Carcinogenicity in Mouse Skin: Methylenedianiline, gamma Glycidyloxytrimethyloxysilane, gamma Aminopropyltriethoxysilane and a Mixture of M-Phenylenediamine, Methylenedianiline, and Diglycidylether of Bisphenol-A

机译：小鼠皮肤中致癌性的测试：亚甲基二苯胺，γ-缩水甘油氧基三甲基氧基硅烷，γ-氨基丙基三乙氧基硅烷和间苯二胺，亚甲基二苯胺和双酚a的二缩水甘油醚的混合物

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Application of graded concentrations of four test substances in acetone to the skin of C3H mice five times a week resulted in the following: gamma aminopropyltriethoxysilane at concentration of 100 and 50 wt/vol % was a severe and mild skin irritant in female C3Hf/Bd respectively and in males a mild skin irritant. Methylenedianiline at a concentration of 10 wt/vol % in methanol killed 4/9 females and 1/9 males. When acetone was the solvent 3/10 females and 3/10 males died within 2 weeks. No mortality or skin damage occurred with gamma glycidyloxytrimethyloxysilane or the mixture of m-phenylenediamine, methylenedianiline and diglycidylether of bisphenol A (MDA). A study of the effects of a two-year, three times a week, topical application of the four test materials revealed no significant increase in skin tumors. The incidence of liver tumors appeared to be increased by exposure to methylenedianiline and with the mixture (MDA). Significant and dose-dependent increases in mortality were found in male mice with MDA and increased mortality at the highest dose (10.8 mg/week) in females. In the case of methylenedianiline excess mortality was found in both sexes. The precise cause of excess mortality from dermal absorption of the materials applied over a two-year period was not established. 5 refs., 12 figs., 12 tabs. (ERA citation 12:033948)

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