• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Impact of Baseline Characteristics on the Effectiveness of Disorder-Specific Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and Supportive Psychotherapy in Outpatient Treatment for Persistent Depressive Disorder
【2h】

Impact of Baseline Characteristics on the Effectiveness of Disorder-Specific Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and Supportive Psychotherapy in Outpatient Treatment for Persistent Depressive Disorder

机译：基线特征对持续抑郁症外门诊治疗疾病特异性认知行为分析体系疗效的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Importance: In the treatment of persistent depressive disorder (PDD), disorder-specific Cognitive Behavioral Analysis System of Psychotherapy (CBASP) has been shown to be superior to Supportive Psychotherapy (SP) in outpatients. It remains to clear which subgroups of patients benefit equally and differentially from both psychotherapies.Objective: To identify those patient-level baseline characteristics that predict a comparable treatment effectiveness of CBASP and SP and those that moderate the differential effectiveness of CBASP compared to SP.Design, setting and participants: In this analysis of a 48-week multicenter randomized clinical trial comparing CBASP to SP in adult antidepressant-free outpatients with early-onset PDD, we evaluated baseline variables from the following domains as potential predictors and moderators of treatment effectiveness: socio-demography, clinical status, psychosocial and global functioning, life quality, interpersonal problems, childhood trauma, treatment history, preference for psychotherapy, and treatment expectancy.Interventions: A 48-week treatment program with 32 sessions of either CBASP or SP.Main outcomes and measures: Depression severity measured by the 24-item Hamilton Rating Scale for Depression (HRSD-24) at week 48.Results: From N = 268 randomized outpatients, N = 209 completed the 48-week treatment program. CBASP completers had significantly lower post-treatment HRSD-24 scores than SP completers (meanCBASP=13.96, sdCBASP= 9.56; meanSP= 16.69, sdSP= 9.87; p = 0.04). A poor response to both therapies was predicted by higher baseline levels of clinician-rated depression, elevated suicidality, comorbid anxiety, lower social functioning, higher social inhibition, moderate-to-severe early emotional or sexual abuse, no preference for psychotherapy, and the history of at least one previous inpatient treatment. Moderator analyses revealed that patients with higher baseline levels of self-rated depression, comorbidity of at least one Axis-I disorder, self-reported moderate-to-severe early emotional or physical neglect, or at least one previous antidepressant treatment, had a significantly lower post-treatment depression severity with CBASP compared to SP (all p < 0.05).Conclusions and relevance: A complex multifactorial interaction between severe symptoms of depression, suicidality, and traumatic childhood experiences characterized by abuse, social inhibition, and anxiety may represent the basis of non-response to psychotherapy in patients with early onset PDD. Specific psychotherapy with CBASP might, however, be more effective and recommendable for a variety of particularly burdened patients compared to SP.
机译：重要性：在治疗持续性抑郁症（PDD）中，表现出心理治疗（CBASP）的紊乱特异性认知行为分析系统，其外分为高于支持性心理治疗（SP）。它仍然可以清除哪些患者的亚组与心理治疗同样和差异地有用。目的：鉴定那些预测CBASP和SP的可比治疗效果的患者级基线特征以及中断CBASP的差异效果的患者级基线特征，设定和参与者：在将CBASP到SP与早盘PDD的未经成人抗抑郁药门诊分析的这种分析中，我们评估了以下域名的基线变量作为潜在的预测因子和治疗效果的主持人：社会人口统计学，临床状况，心理社会和全球性运作，生活质量，人际关系，儿童创伤，治疗史，心理治疗偏好，以及治疗期望。智能化：一个48周的治疗计划，32个CBASP或SP.MAIN结果和措施：24项汉密尔顿测量的抑郁症严重程度第48周的抑郁症（HRSD-24）评级规模。结果：来自N = 268个随机门诊，n = 209完成了48周的治疗计划。 CBASP完成转移后的后处理后HRSD-24比SP完成器（VISCBASP = 13.96，SDCBASP = 9.56;方法= 16.69，SDSP = 9.87; P = 0.04）。通过临床医生抑郁症的基线水平预测对两种疗法的不良反应，升高的自由性，可笑的焦虑，较低的社会功能，更高的社会抑制，中度至严重的早期情绪或性虐待，不偏好心理治疗，而且至少一个先前住院治疗的历史。主持人分析显示，患有较高的基线水平的自我评价抑郁症，至少一个轴 - I紊乱的合并症，自我报告的中度至严重的早期情绪或身体忽视，或至少一个先前的抗抑郁药治疗有显着与CBASP进行治疗后治疗后的抑郁症严重程度（所有P <0.05）。结论和相关性：抑郁症，自由性和创伤性儿童经历的严重症状之间复杂的多因素相互作用，其特征在于滥用，社会抑制和焦虑可能代表早期发病PDD患者心理治疗的基础。然而，与CBASP的具体心理治疗可能会更有效和推荐各种特别负担的患者与SP相比。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号