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Improving the oral bioavailability of drugs through the design of modeled pre-systemic cytochrome P450 inhibitors

机译：通过设计模型化的系统前细胞色素P450抑制剂改善药物的口服生物利用度

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MSc (Med), Faculty of Health Sciences, University of the Witwatersrand, 2010

机译：威特沃特斯兰德大学卫生科学硕士（医学），2010年

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Fasinu Pius Sedowhe;
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年度 2010
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正文语种 en
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1. Dual strategies to improve oral bioavailability of oleanolic acid: Enhancing water-solubility, permeability and inhibiting cytochrome P450 isozymes [J] . Jiang Qikun, Yang Xiaoxu, Du Ping, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2016,第2期

机译：改善齐墩果酸的口服生物利用度的双重策略：提高水溶性，通透性和抑制细胞色素P450同工酶
2. Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 [J] . Fehl Charlie, Vogt Caleb D., Yadav Rahul, Journal of Medicinal Chemistry . 2018,第11期

机译：基于结构的抑制剂的设计，改善了类化细胞色素P450 17A1对细胞色素P450 21A2的选择性
3. P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability [J] . van Hoppe Stephanie, Rood Johannes J. M., Buil Levi, Molecular pharmaceutics . 2018,第11期

机译：p-糖蛋白（MDR1 / ABCB1）限制了Bruton的酪氨酸激酶抑制剂Ibrutinib的脑渗透，而细胞色素P450-3A（CYP3A）限制了其口腔生物利用度
4. A Strategic Approach to Positioning of Cytochrome P450 Studies and Risk Assessment for Drug-Drug Interaction in Drug Discovery [C] . Yamada Yasuhiro International Conference on Cytochrome P450 . 2009

机译：细胞色素P450研究的战略方法，对药物发现中药物互动的研究和风险评估
5. Specificity and mechanism of cytochrome P450s: Use of potent inhibitors and stoichiometric measurements to derive models for binding affinity and coupling efficiency. [D] . Locuson, Charles W., II. 2004

机译：细胞色素P450的特异性和机理：使用有效的抑制剂和化学计量方法得出结合亲和力和偶联效率的模型。
6. Structure-based design of inhibitors with improved selectivity forsteroidogenic cytochrome P450 17A1 over cytochrome P450 21A2 [O] . Charlie Fehl, Caleb D. Vogt, Rahul Yadav, -1

机译：基于结构的抑制剂设计具有更高的选择性类固醇生成细胞色素P450 17A1比细胞色素P450 21A2
7. Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2 [O] . Charlie Fehl, Caleb D. Vogt, Rahul Yadav, 2018

机译：基于结构的抑制剂的设计，改善了类化细胞色素P450 17A1对细胞色素P450 21A2的选择性

Improving the oral bioavailability of drugs through the design of modeled pre-systemic cytochrome P450 inhibitors

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