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Use of ERPY-LIKE as an immunobiology in the control of leprosyrosis

机译：ERP-LIKE作为免疫学在控制钩端螺旋体病中的应用

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摘要

The patent relates to the isolation of a DNA molecule originally derived from 1. interrogans. its sequence codes for erpy-like protein (lic11966), reported as a protein that has a sequence very similar to virulence factors found in other pathogens. In addition, its expression has been demonstrated during in vivo infection, which makes it A promising target for infection therapy, whether preventively as a vaccine or vaccine component, in the formulation of leptospirosis diagnostic kits, or in the production of tools such as monoclonal antibodies for use in treating the infection. According to the present invention can erpy-like protein and its coding sequence be used in the diagnosis, treatment and prevention of infection by pathogenic strains of leptospira spp., etiological agent of leptospirosis? disease of global importance affecting human and animal health.

机译：该专利涉及最初源自问号的DNA分子的分离。它的序列编码erpy-like蛋白（lic11966），报道为一种蛋白，其序列与其他病原体中发现的毒力因子非常相似。此外，它的表达已在体内感染过程中得到证实，这使其成为感染治疗的有希望的靶标，无论是作为疫苗还是疫苗成分进行预防，在钩端螺旋体病诊断试剂盒的配制中或在工具生产中（如单克隆抗体）用于治疗感染。根据本发明，erpy样蛋白及其编码序列可用于诊断，治疗和预防由钩端螺旋体病病原体钩端螺旋体病原体引起的感染吗？影响人类和动物健康的具有全球重要性的疾病。

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公开/公告号BR102016018203A2

专利类型
公开/公告日2018-03-06

原文格式PDF
申请/专利权人 UNIVERSIDADE FEDERAL DE PELOTAS;
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申请/专利号BR20161018203
发明设计人 BÁRBARA COUTO ROLOFF;CAROLINE GOMES LUCAS;DAIANE DRAWANZ HARTWIG;FABIANA KOMMLING SEIXAS;ODIR ANTÔNIO DELLAGOSTIN;RODRIGO ANDRADE SCHUCH;THAÍS FARIAS COLLARES;THAÍS LARRÉ OLIVEIRA;
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申请日2016-08-08
分类号A61K39/02;A61P31/04;C07K14/20;C12N15/31;G01N33/569;
国家 BR
入库时间 2022-08-21 12:54:03

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