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A method for regulation of cellular behaviors by applying electric stimulus based on enzymatic biofuel cell
A method for regulation of cellular behaviors by applying electric stimulus based on enzymatic biofuel cell
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机译：一种基于酶促生物燃料电池的电刺激调控细胞行为的方法
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摘要
The present invention relates to a method for regulating cell movement, a composition for inducing stem cell differentiation, and a composition for promoting cell migration or proliferation, which comprises the step of applying electrical stimulation to a cell using an enzymatic biofuel cell; A cell culture vessel equipped with an enzymatic biofuel cell and capable of culturing cells while applying electric stimulation thereto; Pharmaceutical compositions for the prevention and treatment of wounds, diseases caused by muscle tissue abnormalities, bone diseases and neurological diseases, including enzymatic biofuel cells; And a muscle cell, osteocyte, neuron, and myocardial cell differentiated by using the stem cell differentiation inducing composition or cell culture container. The method for controlling cell behavior by applying electrical stimulation using the enzyme biofuel cell according to the present invention is characterized by high biocompatibility and moldability to a desired formulation by using an enzyme as an electric stimulus source, It is possible to generate a wide range of currents and to generate electric stimulation even if both electrodes are not included. Therefore, the present invention is highly likely to be used as a pharmaceutical composition. In addition, when different levels of electrical stimulation are applied at a level that does not induce apoptosis, stem cells can be induced to differentiate into different tissues, so that they can be variously formulated and useful for tissue regeneration.
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