首页> 外国专利> 'isolation and characterization of a novel urea impurity compound 1-1r,2s)-2-(3,4-difluorophenyl) cyclopropyl-3-(1r,2s)-2-3,4-difluorophenyl cyclopropyl-3-(1r,2s)-2-(3,4-difluorophenyl) cyclopropyl urea and its use in the synthesis of ticagrelor'

'isolation and characterization of a novel urea impurity compound 1-1r,2s)-2-(3,4-difluorophenyl) cyclopropyl-3-(1r,2s)-2-3,4-difluorophenyl cyclopropyl-3-(1r,2s)-2-(3,4-difluorophenyl) cyclopropyl urea and its use in the synthesis of ticagrelor'

机译：“新型尿素杂质化合物1- [1r，2s）-2-（3,4-二氟苯基）环丙基-3-（1r，2s）-2- [3,4-二氟苯基]环丙基-3-酯的分离和表征（1r，2s）-2-（3,4-二氟苯基）环丙基脲及其在替卡格雷的合成中的应用”

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摘要

"Isolation and characterization of a Novel Urea impurity compound l-(lR,2S)-2-(3,4-Difluorophenyl)cyclopropyl-3--(1R,2S)-2-(3,4-Dif luorophenyl) cyclopropyl urea and its use in the synthesis of Ticagrelor" The present invention provides isolation and characterization of a novel urea impurity compound related to (1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl amine (CP-Amine), processes for its preparation and its use as Reference standard to control the quality of CP-Amine . The present invention also describes the use of above solid urea compound of CP-Amine for the synthesis of specific intermediates, suitable for the preparation of triazolo-pyrimidine compounds, such as Ticagrelor.

机译：“新型尿素杂质化合物1-（lR，2S）-2-（3,4-二氟苯基）环丙基-3-（1R，2S）-2-（3,4-Dif氟苯基）环丙基脲的分离和表征及其在替卡格雷的合成中的用途本发明提供了与（1R，2S）-2-（3,4-二氟苯基）环丙胺（CP-Amine）有关的新型脲杂质化合物的分离和表征，制备及其作为控制CP-胺质量的参考标准。本发明还描述了上述CP-胺的固体脲化合物在合成特定中间体中的用途，该中间体适合于制备三唑并嘧啶化合物，例如替卡格雷。

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公开/公告号IN2013MU03779A

专利类型
公开/公告日2015-12-04

原文格式PDF
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申请/专利号IN3779/MUM/2013
发明设计人 RASADIA PUNITKUMAR RAMESHBHAI;RAMANI VAIBHAV NARENDRAKUMAR;SHAH ANAMIK KANTILAL;
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申请日2013-12-03
分类号C07C273;C07D487;
国家 IN
入库时间 2022-08-21 14:25:32

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