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Neisseria meningitidis, high-level expression, purification and refolding of group B outer membrane porin proteins
Neisseria meningitidis, high-level expression, purification and refolding of group B outer membrane porin proteins
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机译:脑膜炎奈瑟氏球菌,B组外膜孔蛋白的高水平表达,纯化和重折叠
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摘要
The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins yard fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
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