摘要：
基于气相色谱-串联质谱(GC-MS/MS)技术建立了6种防腐剂总量及迁移量的测定方法,通过搭建迁移装置并模拟实际暴露场景,对自制阳性样品中6种防腐剂在模拟唾液和汗液中的迁移规律进行研究,并计算出不同时刻的迁移率.结果表明,在迁移2 min～ 96 h范围内,防腐剂的迁移量均随时间延长而逐渐增大,最终达到迁移平衡,迁移率为2.1％～61.7％(唾液),2.2％ ～ 86.4％(汗液).在样品与模拟液仅接触2 min时有6种物质检出,迁移率分别为2.1％～4.2％(唾液)和2.2％～3.3％(汗液).部分实际样品中检出了2,4-二氯苯酚和2,4,6-三氯苯酚,鉴于儿童日常生活中短时间持续接触样品的特点,选取两个实际阳性样品测定了其在2～30 min的迁移量及迁移率.%In this paper,a GC-MS/MS method was established for the determination of the residue and migration amounts of six preservatives.The migration regularity of six preservatives from sample to simulated saliva and sweat was studied,and the migration rates at different times were calculated through building a self-made migration device to simulate the actual exposure scenarios.The results showed that the migration amount of preservatives gradually increased with time in range of 2 min to 96 h,and finally reached the migration equilibrium.The migration rates in saliva and sweat were in the ranges of 2.1％-61.7％ and 2.2％-86.4％,respectively.It was worth noting that when the sample was in contact with the simulated solution for only 2 min,the analytes could be detected,and the migration rates in saliva and sweat were 2.1％-4.2％ and 2.2％-3.3％,respectively.Some commercial samples were detected to contain 2,4-DCP and 2,4,6-TCP.Due to the characteristics of children's daily short duration contacting with the sample,two positive samples were selected for the determination of their migration amounts and migration rates in 2-30 min.
