An Alternative Lidocaine Hydrochloride Liposomal Gel Formulation : Preparation, Percutaneous Permeation and Release Kinetics

机译：盐酸利多卡因的另一种脂质体凝胶制剂：制备，经皮渗透和释放动力学

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Liposomal hydrogel formulations of lidocaine hydrochloride(LDH)have been prepared and drug percutaneous permeation and release properties in vitro have been evaluated. An optimal hydrogel prescription with carbopol as base involved permeation enhancers as polyethylene glycol (PEG-400), Azone, poloxamer and propylene glycol was screened in vitro. Percutaneous permeation kinetic models of LDH in three formulations: liposome solution, conventional gel and liposomal gel were studied.

机译：制备了利多卡因盐酸盐（LDH）的脂质体水凝胶制剂，并评估了药物在体外的经皮渗透和释放特性。以卡波姆为基础的最佳水凝胶处方涉及渗透促进剂，如体外筛选的聚乙二醇（PEG-400），Azone，泊洛沙姆和丙二醇。研究了三种制剂中LDH的经皮渗透动力学模型：脂质体溶液，常规凝胶和脂质体凝胶。

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《The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议）论文集》|2009年|1-4|共4页
会议地点 Beijing(CN)
作者
Xue-Nong ZhANG; Jin-hong Gong; Yang Liu; Li-hua Tang; Xiao-jun Xu;
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作者单位

College of Pharmacy Soochow University Suzhou 215123 People's Republic of China;

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关键词
Lidocaine hydrochloride (LDH); Liposome; Gel; Percutaneous permeation;

机译：盐酸利多卡因（LDH）;脂质体;凝胶;经皮渗透;

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1. An alternative lidocaine hydrochloride liposomal gel formulation: preparation, percutaneous permeation, and release kinetics. [J] . Gong JH, Liu Y, Tang LH, PDA journal of pharmaceutical science and technology . 2006,第4期

机译：盐酸利多卡因的另一种脂质体凝胶制剂：制备，经皮渗透和释放动力学。
2. Effect of permeation enhancers on the release and permeation kinetics of Lincomycin hydrochloride gel formulations through mouse skin [J] . Panigrahi L, Ghosal S, Pattnaik S, Indian journal of pharmaceutical sciences. . 2006,第2期

机译：渗透促进剂对盐酸林可霉素凝胶制剂通过小鼠皮肤释放和渗透动力学的影响
3. Hydrophilic nasal gel of lidocaine hydrochloride. 1st Communication: Preparation, formulation optimization and in vitro release study. [J] . Hu KL, Mei N, Feng Arzneimittel-Forschung: =Drug Research . 2009,第11期

机译：盐酸利多卡因的亲水性鼻凝胶。第一次交流：制备，配方优化和体外释放研究。
4. An Alternative Lidocaine Hydrochloride Liposomal Gel Formulation : Preparation, Percutaneous Permeation and Release Kinetics [C] . Xue-Nong Zhang, Jin-Hong Gong, Yang Liu, Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：盐酸利多卡因的另一种脂质体凝胶制剂：制备，经皮渗透和释放动力学
5. 1. Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs, 2. In vitro-in vivo evaluation of nicardipine HCl sustained-release formulations [D] . Sorasuchart, Waranush. 1998

机译：1.评估聚卡波非包衣的脂质体和游离药物和脂质体药物的膜渗透性，2.尼卡地平HCl缓释制剂的体外-体内评估
6. Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation [O] . Mahmoud M Omar, Omiya Ali Hasan, Amani M El Sisi 2019

机译：含有渗透增强剂的利多卡因转运体凝胶的制备和优化：增强皮肤渗透性的有前途的方法
7. Lidocaine permeation from a lidocaine NaCMC:gel microgel formulation in microneedle pierced skin: vertical (depth averaged) and horizontal permeation profiles [O] . Nayak Atul, Short Liam, Das Diganta Bhusan 2015

机译：利多卡因NaCMC：凝胶微凝胶制剂在微针刺穿皮肤中的利多卡因渗透：垂直（深度平均）和水平渗透曲线

An Alternative Lidocaine Hydrochloride Liposomal Gel Formulation : Preparation, Percutaneous Permeation and Release Kinetics

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