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首页> 外文会议>Advanced bioactive compounds countering the effects of radiological, chemical and biological agents : Strategies to counter biological damage >Radioprotective Properties of Selenomethionine with Methionine, Extracts from Basidium Fungi and Exogenous DNA
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Radioprotective Properties of Selenomethionine with Methionine, Extracts from Basidium Fungi and Exogenous DNA

机译：硒代蛋氨酸，蛋氨酸真菌提取物和外源DNA对硒代蛋氨酸的辐射防护性能

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The search for effective substances to provide protection to the organism under radiation treatment continues to be one of the most important directions for studies in radiobiology. The results of the study show that selenmethionine in the indicated doses with methionine (4 mg/kg) have pronounced efficiency on the defense of organisms against acute irradiation at a dose of 2 Gy. This was shown in the recovery of leucocytes in the blood, the increase in the total number of sper-matogenic cells, and a significant increase in the spermatid count by 2 months after irradiation (2.3-2.6 times). This may provide a restoration in the process of sper-matogenesis as well as normalization of lipid peroxidation processes and transami-nation enzymes activities in the irradiated animals. We also studied the anti-tumoral and radioprotective activities of the mushroom aqueous extracts. The antitumoral properties of Flammulina velutipes are shown. Its aqueous extracts decrease a spontaneous level of adenomas and, as well as Auricularia auricular-judae, reduce the yield of urethane-induced adenomas. The aqueous extracts of Flammulina velutipes and Phallus impudicus demonstrate radioprotective properties, i.e. reduce a number of adenomas in irradiated mice, raise mice survival and stimulate a growth of endogenous colonies in spleen. We prepared and studied the exogenous DNA. Micronuclei tests of bone marrow show an improvement in the DNA repair process in erythro-blasts of irradiated and treated animals. Based on PCR analysis, it was suggested that the exogenous DNA substance can protect cardiac cells from the activation of pro-apoptotic gene Bax, and it can rescue the heart from irradiation-induced apoptosis. Thus the studied substances can be promising agents for protection and recovery of an organism from radiation injury.
机译：寻找有效的物质为放射治疗的生物提供保护，仍然是放射生物学研究的最重要方向之一。研究结果表明，在指定剂量的蛋氨酸（4 mg / kg）中，硒代蛋氨酸在2 Gy剂量下具有显着的防御微生物抵御急性辐射的功效。辐射后2个月（2.3-2.6倍），血液中白细胞的恢复，生精细胞总数的增加以及精子数量的显着增加表明了这一点。这可以提供受精动物生精过程的恢复，以及脂质过氧化过程和转氨酶活性的正常化。我们还研究了蘑菇水性提取物的抗肿瘤和辐射防护活性。显示了金针菇的抗肿瘤特性。其水提取物可降低自发性腺瘤水平，以及黑木耳（Auricularia auricular-judae）也可降低氨基甲酸酯诱导的腺瘤的产量。金针菇和阴茎阳茎的水提取物具有辐射防护性能，即减少受辐照小鼠的腺瘤数量，提高小鼠存活率并刺激脾脏内源菌落的生长。我们准备并研究了外源DNA。骨髓的微核试验显示，辐照和治疗动物的红细胞中DNA修复过程得到了改善。基于PCR分析，表明外源DNA物质可以保护心肌细胞免于促凋亡基因Bax的活化，并且可以使心脏免于辐射诱导的细胞凋亡。因此，所研究的物质可以成为有希望的保护和恢复生物免受辐射伤害的药物。

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