Combined time- and depth-resolved autofluorescence spectroscopy for tissue diagnosis

机译：结合时间和深度分辨的自发荧光光谱进行组织诊断

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A fluorescence spectroscopy system combining depth- and time-resolved measurements is developed to investigate the layered fluorescence temporal characteristics of epithelial tissue. It is found that esophageal tissue structure can be resolved well by means of the autofluorescence time-resolved decay process with 375-, 405- and 435- nm excitation. The decay of the autofluorescence signals can be accurately fitted with a dual-exponential function consisting of a short lifetime (0.4 ～ 0.6 ns) and a long lifetime (3 ～ 4 ns) components. The short lifetime component dominates the decay of normal epithelial fluorescence while the decay of the signals from keratinized epithelium and stroma are mainly determined by the long lifetime component. The ratio of the amplitudes of two components provides the information of fine structure of epithelial tissue. This study demonstrates that the combined depth- and time-resolved measurements can potentially provide accurate information for the diagnosis of tissue pathology.

机译：开发了一种结合深度和时间分辨测量结果的荧光光谱系统，以研究上皮组织的分层荧光时间特性。发现通过375-，405-和435-nm激发的自发荧光时间分辨衰变过程可以很好地分辨食道组织结构。自发荧光信号的衰减可以通过具有短寿命（0.4〜0.6 ns）和长寿命（3〜4 ns）的双指数函数精确拟合。短寿命成分占正常上皮荧光衰减的主要部分，而角化上皮和基质的信号衰减主要取决于长寿命成分。两个分量的振幅之比提供了上皮组织的精细结构的信息。这项研究表明，结合深度和时间分辨的测量可以潜在地为组织病理学诊断提供准确的信息。

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《Advanced Biomedical and Clinical Diagnostic Systems IV; Progress in Biomedical Optics and Imaging; vol.7 no.3》|2006年|P.608018.1-608018.5|共5页
会议地点 San JoseCA(US)
作者
Yicong Wu; Jianan Y. Qu;
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作者单位

Department of Electrical Electronic Engineering, Hong Kong University of Science Technology, Clear Water Bay Road, Kowloon, Hong Kong, P. R. China;

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原文格式 PDF
正文语种 eng
中图分类光、激光生物医学;
关键词
time-resolved; depth-resolved; tissue autofluorescence; keratinized;

机译：时间分辨；深度分辨；组织自发荧光；角质化;

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专利

1. Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis [J] . Sun Y, Liu R, Elson DS, Optics Letters . 2008,第6期

机译：同时时间和波长分辨荧光光谱用于近实时组织诊断
2. Combining near-infrared-excited autofluorescence and Raman spectroscopy improves in vivo diagnosis of gastric cancer [J] . Bergholt M.S., Zheng W., Lin K., Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices . 2011,第10期

机译：近红外激发自发荧光和拉曼光谱的结合改善了胃癌的体内诊断
3. Endoscopic ultraviolet-induced autofluorescence spectroscopy of the esophagus: tissue characterization and potential for early cancer diagnosis. [J] . Bourg-Heckly G, Blais J, Padilla JJ, Endoscopy: Journal for Clinical Use Biopsy and Technique . 2000,第10期

机译：内窥镜食管的紫外线诱导自发荧光光谱：组织表征和早期癌症诊断的潜力。
4. Combined time- and depth-resolved autofluorescence spectroscopy for tissue diagnosis [C] . Yicong Wu, Jianan Y. Qu, SPIE-The International Society for Optical Engineering Conference on Advanced Biomedical and Clinical Diagnostic Systems . 2006

机译：组合组织诊断的组合和深度分辨的自发荧光光谱
5. Autofluorescence spectroscopy of epithelial tissue. [D] . Wu, Yicong. 2007

机译：上皮组织的自发荧光光谱。
6. Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis [O] . Yinghua Sun, Yang Sun, Douglas Stephens, -1

机译：使用时间和波长分辨荧光光谱进行动态组织分析以诊断动脉粥样硬化
7. Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis [O] . Sun Y, Stephens D, Xie H, 2011

机译：使用时间和波长分辨荧光光谱法进行动态组织分析，用于动脉粥样硬化的诊断

Combined time- and depth-resolved autofluorescence spectroscopy for tissue diagnosis

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