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Tissue classification using terahertz pulsed imaging

机译:使用太赫兹脉冲成像的组织分类

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We demonstrate the application of terahertz pulsed imaging (TPI) in reflection geometry as a diagnostic aid for epithelial cancer, specifically basal cell carcinoma. Epithelial cancer, which includes skin, breast and colon cancer, accounts for about 85% of all cancers. The terahertz (THz) region is typically defined in the frequency range of 0.1-10 THz. The sensitivity of terahertz radiation to water makes TPI an ideal technique for the study of skin, particularly as cancerous tissue has been shown to contain more water than normal tissue. Twenty-one ex vivo skin samples from a previous study, which successfully identified all 17 samples exhibiting basal cell carcinoma, were analysed in detail using time-domain algorithms to determine the role of TPI as a diagnostic aid. Eight parameters were assessed, four of which were identified as uncorrelated. The samples were classified into two groups: diseased tissue, and tissue without disease. A sensitivity and specificity greater than 80 % for six of the parameters was attained. These results demonstrate the potential of TPI as a diagnostic aid.
机译:我们展示了太赫兹脉冲成像(TPI)在反射几何中的应用,作为上皮癌特别是基底细胞癌的诊断辅助。上皮癌包括皮肤癌,乳腺癌和结肠癌,约占所有癌症的85%。太赫兹(THz)区域通常在0.1-10 THz的频率范围内定义。太赫兹辐射对水的敏感性使TPI成为研究皮肤的理想技术,特别是因为已证明癌组织比正常组织含有更多的水。使用时域算法详细分析了先前研究的21个离体皮肤样品,该样品成功鉴定了所有17个表现出基底细胞癌的样品,以确定TPI作为诊断辅助剂的作用。评估了八个参数,其中四个被确定为不相关。将样品分为两组:患病组织和无病组织。对于六个参数,灵敏度和特异性均大于80%。这些结果证明了TPI作为诊断助剂的潜力。

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