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首页> 外文会议>Conference on optical coherence tomography and coherence domain optical methods in biomedicine XIII; 20090126-28; San Jose, CA(US) >Spectral Doppler Imaging of Micro-vasculature Response to Laser Irradiation
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Spectral Doppler Imaging of Micro-vasculature Response to Laser Irradiation

机译：光谱多普勒成像的微血管对激光辐照的响应

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摘要

Doppler Optical Coherence Tomography (DOCT) imaging of in-vivo retinal blood flow was widely studied as efforts of research community to push this technology into clinic. Spectral Doppler imaging of DOCT has been demonstrated as a quantification method of in-vivo pulsatile retinal blood flow in human eye. This technology has the all the advantages inherited from OCT comparing to Doppler ultrasound. Comparing to normal spatial-distributed color Doppler imaging of DOCT, spectral Doppler imaging can reveal more haemodynamics details on the time dimension. Although resistance index (RI) of a micro-vascular can be measured in vivo from human retina, the clinical significance of RI measurements still needs to be investigated. In vitro experiment conduced with ultrasound has demonstrated the higher vascular resistance value is associated with the higher RI measured assuming the constant compliance of vascular tube. In this study, the rodent window-chamber model (RWCM) was used as a platform to investigate the RI change as the micro-vasculature response to laser irradiation. The higher RI was measured after the occlusion of two veins (should it be arterials) that was verified with laser speckle imaging in our preliminary experiment results.
机译：随着研究界将这项技术推向临床的努力，对体内视网膜血流的多普勒光学相干断层扫描（DOCT）成像进行了广泛研究。已经证明DOCT的频谱多普勒成像是人眼中体内脉动性视网膜血流的定量方法。与多普勒超声相比，该技术具有OCT所继承的所有优势。与正常的DOCT空间分布彩色多普勒成像相比，频谱多普勒成像可以在时间维度上揭示更多的血液动力学细节。虽然可以从人视网膜体内测量微血管的抵抗指数（RI），但仍需要研究RI测量的临床意义。超声进行的体外实验表明，假定血管管的顺应性，较高的血管阻力值与较高的RI相关。在这项研究中，以啮齿动物窗室模型（RWCM）为平台，研究RI变化作为对激光照射的微脉管反应。在我们初步的实验结果中，通过激光散斑成像验证了两条静脉（应该是动脉）的阻塞后，测量出较高的RI。

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