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首页> 外文会议>Conference on optical coherence tomography and coherence domain optical methods in biomedicine >Spectral Doppler Imaging of Micro-vasculature Response to Laser Irradiation
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Spectral Doppler Imaging of Micro-vasculature Response to Laser Irradiation

机译：激光辐射微脉管系统响应的光谱多普勒成像

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Doppler Optical Coherence Tomography (DOCT) imaging of in-vivo retinal blood flow was widely studied as efforts of research community to push this technology into clinic. Spectral Doppler imaging of DOCT has been demonstrated as a quantification method of in-vivo pulsatile retinal blood flow in human eye. This technology has the all the advantages inherited from OCT comparing to Doppler ultrasound. Comparing to normal spatial-distributed color Doppler imaging of DOCT, spectral Doppler imaging can reveal more haemodynamics details on the time dimension. Although resistance index (RI) of a micro-vascular can be measured in vivo from human retina, the clinical significance of RI measurements still needs to be investigated. In vitro experiment conduced with ultrasound has demonstrated the-higher vascular resistance value is associated with the higher RI measured assuming the constant compliance of vascular tube. In this study, the rodent window-chamber model (RWCM) was used as a platform to investigate the RI change as the micro-vasculature response to laser irradiation. The higher RI was measured after the occlusion of two veins (should it be arterials) that was verified with laser speckle imaging in our preliminary experiment results.
机译：多普勒光学相干断层扫描（Doct）In-Vivo视网膜血流的成像被广泛研究了研究界的努力，将这种技术推入诊所。 DOP的光谱多普勒成像被证明为人眼中体内脉冲视网膜血流的量化方法。该技术具有从OCT继承的所有优势与多普勒超声波相比。与Doct的正常空间分布式颜色多普勒成像相比，光谱多普勒成像可以揭示关于时间尺寸的更多血液动力学细节。尽管微血管的抗性指数（RI）可以在人视网膜体内测量，但仍需要研究RI测量的临床意义。用超声导致的体外实验已经证明 - 较高的血管阻力值与假设血管管常数依从性测量的较高的RI相关。在该研究中，啮齿动物窗口腔室模型（RWCM）用作研究RI变化作为对激光照射的微脉管系统响应的平台。在我们的初步实验结果中通过激光散斑成像进行验证后，测量较高的RI在两个静脉（应该是动脉）。

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